Sökning: "immunotherapy"

Visar resultat 1 - 5 av 55 uppsatser innehållade ordet immunotherapy.

  1. 1. Assessment and evaluation of heterogeneity in data from immune infiltration spatial niches in lung cancer

    Kandidat-uppsats, Lunds universitet/Matematisk statistik

    Författare :Mahta Keivani Najafabadi; [2023]
    Nyckelord :Mathematics and Statistics;

    Sammanfattning : The protein biomarker expressions in three types of sampled immune INFILTration spatial niches in lung cancer tissue were measured using the new technology Digital Spatial Profiler (DSP). The three types of immune INFILTration that were observed in lung tumors were STROMA identified as immune cells separate from tumor cells, Tertiary lymphoid structures (TLS) identified as dense structures of organized immune cells and finally Infiltraterate where immune cells dispersed among and in direct contact with tumor cells (INFILT). LÄS MER

  3. 2. Comparison of deep learning and model-based approaches for spatial profiling of the immune tumor environment on multiplex image data

    Master-uppsats, Uppsala universitet/Institutionen för informationsteknologi

    Författare :Esraa Ahmed; [2023]
    Nyckelord :;

    Sammanfattning : The demographics of the tumor microenvironment (TME) impact the Immunotherapy responses for lung cancer patients. Given the heterogeneity of immune cells present within TME, the distribution patterns of different subpopulations of T-cells can be exploited to predict short-term or long-term survival of lung cancer patients. LÄS MER

  4. 3. Genetic manipulation to improve efficacy of dendric cell adoptive immunotherapy against cancer in dogs

    Kandidat-uppsats, Karlstads universitet

    Författare :Felicia Berglund; [2023]
    Nyckelord :Adoptive immunotherapi;

    Sammanfattning : To improve the efficacy of the dendritic cell vaccine Alv B DC from Alv B, the PD-L1 expression in cancer cells was attempted to be reduced through a transfection with a custom designed siRNA. Before transfecting the dendritic cells, the siRNA functionality had to be tested through flow cytometry, that resulted in negative results and therefore led to a RT-qPCR protocol that indicated that the siRNA was functional. LÄS MER

  5. 4. Predicting tumour growth-driving interactions from transcriptomic data using machine learning

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Neuroonkologi och neurodegeneration

    Författare :Mathilda Stigenberg; [2023]
    Nyckelord :cancer; immunology; cell-cell interactions; deep learning; variational autoencoder; supervised variational autoencoder; tumour microenvironment; single-cell RNA sequencing; spatial transcriptomics; breast cancer; machine learning;

    Sammanfattning : The mortality rate is high for cancer patients and treatments are only efficient in a fraction of patients. To be able to cure more patients, new treatments need to be invented. Immunotherapy activates the immune system to fight against cancer and one treatment targets immune checkpoints. LÄS MER

  7. 5. Kvinnors upplevelser efter mastektomi ur ett livsvärldsperspektiv : En litteraturöversikt

    Kandidat-uppsats, Högskolan i Borås/Akademin för vård, arbetsliv och välfärd

    Författare :Nassim Husseini; Ikraan Mohamud Mohamed; [2023]
    Nyckelord :Breast cancer; Mastectomy; Women; Body image; Life world; Suffering; Support; Bröstcancer; Mastektomi; Kvinnor; Kroppsuppfattning; Livsvärld; Lidande; Stöd;

    Sammanfattning : Bakgrund: Bröstcancer är den vanligaste cancerdiagnosen hos kvinnor i Sverige. Behandlingar för bröstcancer kan vara strålbehandling, immunterapi, cytostatika och kirurgisk behandling som till exempel mastektomi. LÄS MER