Sökning: "in-vivo mutation"

Visar resultat 1 - 5 av 9 uppsatser innehållade orden in-vivo mutation.

  1. 1. Validation of a 3D culture model for toxicity studies in malignant and non-cancerous cells

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Kajsa Andreasson Dahlgren; [2021]
    Nyckelord :Dose-response; potency; in vitro; 2D model; 3D model; cancer; MEK inhibitor; trametinib; A549; LL47; Western blot; Biology and Life Sciences;

    Sammanfattning : Cancer is a widespread and commonly fatal disease in constant need of new treatments. Traditionally, new pharmaceuticals have been tested in 2D models. This is not ideal, as 2D environments do not reflect the in vivo milieu of the cells. LÄS MER

  3. 2. A pericyte-specific knockout of Foxf2 in mice shows fibrinogen acculumation in the brain but no regulation in Pdgfr-ß expression

    Kandidat-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Ebba Stål; [2021]
    Nyckelord :;

    Sammanfattning : FoxF2 is a transcriptional factor that initiates gene expression. Foxf2 is particularly expressed in central nervous system pericytes. Recent studies have displayed that an inactivation of Foxf2 in mice had an impact on the blood-brain barrier integrity with evidence of breakdown. LÄS MER

  4. 3. Interactions between Rho-ROCK signaling and the tumor microenvironment in neuroblastoma

    Master-uppsats, Uppsala universitet/Mikrobiologi och immunologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Adena Pepich; [2021]
    Nyckelord :cancer and oncology; pediatric cancer; neuroblastoma; rho ROCK signaling; rho-associated kinases; tumor microenvironment; cytotoxic T cells; neuroblastom; pediatrik onkologi; rho-kinaser;

    Sammanfattning : Neuroblastoma is a childhood cancer of the peripheral sympathetic nervous system, emerging from cells of the neural crest. In Sweden, neuroblastoma accounts for 20 cases out of all, 300-350, pediatric cancer cases each year (Barncancerfonden 2019, Turup on behalf of Cancer Centrum 2019). LÄS MER

  5. 4. Characterization of the fusion protein mNG-Aβ1-42 as a fluorescence reporter probe for amyloid structure

    Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Linnéa Fredén; [2020]
    Nyckelord :Alzheimer’s Disease AD ; Amyloids; Aβ; fusion protein; mNeonGreen; mNG-Aβ1-42; Crystallization; mouse brain tissue; human brain tissue; amyloid fluorescent probes;

    Sammanfattning : Alzheimer’s Disease, also called AD, is a horrible, degenerative brain disease that more than 35 million people over the world have. Today, there is no cure for this disease, only treatments that are temporarily relieving the symptoms. The two proteins that is thought to be the main cause of AD is amyloid β (Aβ) and tau. LÄS MER

  7. 5. Fluorescent fusion proteins as probes to characterize tau fibril polymorphism

    Master-uppsats, Linköpings universitet/Kemi

    Författare :Max Lindberg; [2019]
    Nyckelord :Alzheimer’s disease AD ; amyloids; FRET; tau; MAPT; fibrillation kinetics; seeding; fusion protein; EGFP; ECFP; EYFP; ThT; X-34; BTD14;

    Sammanfattning : Alzheimer's disease (AD) is a large and growing problem and while we today lack a full understanding of this disease, we know that the protein tau and the amyloid fibrils it forms play a central role in its development. We also know that these fibrils can have different morphologies in different diseases and that fibrils produced in vitro not necessarily adopt any of the morphologies found in patients. LÄS MER