Sökning: "intrinsically disordered proteins"

Visar resultat 1 - 5 av 7 uppsatser innehållade orden intrinsically disordered proteins.

1. 1. Competition between Phase Separation and Micellization in a Coarse-Grained Protein Model with Two Components

   Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation; Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

   Författare :Fangxuan Lyu; [2022]
   Nyckelord :Physics and Astronomy;

   Sammanfattning : Intrinsically disordered proteins (IDPs) are widely believed to play a key role in the for- mation of intracellular biomolecular condensates through liquid-liquid phase separation (LLPS). Furthermore, it has been shown in vitro that several IDPs are able to phase sepa- rate on their own. LÄS MER

3. 2. Investigating Minor States of the Oncoprotein N-MYC, with Focus on Proline Cis/Trans Isomerisation using NMR Spectroscopy

   Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

   Författare :Frida Haugskott; [2021]
   Nyckelord :Myc; N-Myc; Intrinsically Disordered protein IDP ; Proline; cis-trans isomerisation; minor conformation; NMR; cancer;

   Sammanfattning : MYC is a family of three regulator genes that codes for transcription factors. Expression of Myc proteins from MYC genes is found to be deregulated in 70 % of all cancer forms. The three human homologs C-Myc, N-Myc and L-Myc are mainly associated with cancer in the lymphatic system, nerve tissues and lung cancer, respectively. LÄS MER

4. 3. Evaluating a coarse-grained IDP-model for structure and dynamics

   Kandidat-uppsats, Lunds universitet/Biofysikalisk kemi

   Författare :Louise Kalander; [2021]
   Nyckelord :IDP; Intrinsically disordered proteins; Histatin 5; Simulation; Biophysical chemistry; Chemistry;

   Sammanfattning : In this study a coarse-grained model of intrinsically disordered proteins (IDPs) is evaluated to determine whether the model is suitable to use for analyzing the structure and dynamics of IDPs. IDPs are proteins that lack a stable tertiary structure which gives them a flexible structure. LÄS MER

5. 4. Liquid-Liquid Phase Separation of HP Lattice Proteins: A Finite-Size Scaling Analysis

   Master-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

   Författare :Markus Ernstsson; [2020]
   Nyckelord :LLPS; Finite-size scaling; Protein droplets; Biomolecular condensates; Monte Carlo; Lattice gas; Multicanonical simulations; Phase diagram; Physics and Astronomy;

   Sammanfattning : Biomolecular condensates are dense droplets of proteins and nucleic acids inside living cells that form through a liquid-liquid phase separation (LLPS) process, in which intrinsically disordered proteins (IDPs) often play an important role. Furthermore, it has been shown that several of these IDPs can form similar droplets on their own. LÄS MER

7. 5. Specificity and characteristics of fuzzy complexes -- Modelling of intrinsically disordered proteins

   Kandidat-uppsats, Lunds universitet/Beräkningsbiologi och biologisk fysik - Genomgår omorganisation

   Författare :Karolina Mothander; [2015]
   Nyckelord :specificity; Monte Carlo; Fuzzy complexes; Intrinsically disordered proteins; Physics and Astronomy;

   Sammanfattning : Intrinsically disordered proteins are fully functional proteins without a three-dimensional structure. Intrinsically disordered proteins can, in the same way as ordered proteins, interact with other proteins to fulful their function. LÄS MER