Sökning: "leukotoxin"

Visar resultat 1 - 5 av 9 uppsatser innehållade ordet leukotoxin.

  1. 1. Analysis of a Filifactor Alocis genotype and its effect on pathological progress in periodontitis

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Tandläkarutbildning

    Författare :Jessica Radu; Kati Heinämäki; [2021]
    Nyckelord :;

    Sammanfattning : Background: Filifactor alocis is a gram positive, obligate anaerobic rod bacterium that has shown correlation to pathogenic events that may be linked to periodontitis. Previous studies have proved the presence of so-called “rtx” toxins in F. alocis that are similar to the leukotoxin of A. actinomycetemcomitans. LÄS MER

  3. 2. Analysis of selected virulence properties of Filifactor alocis

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Merna Jajo; Nikolina Sjöblom; [2018]
    Nyckelord :Filifactor alocis;

    Sammanfattning : ABSTRACT Filifactor alocis is a gram-positive rod-shaped bacterium, and several studies have demonstrated that the species is associated with periodontal disease. It has several proteins and properties that makes it a potential partner in crime in a disease process. Here we studied a small collection of 10 isolates of F. LÄS MER

  4. 3. Characterization of Macrophage Activation Induced by Leukotoxin from Aggregatibacter actinomycetemcomitans 

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Niklas Sundling; Lisa Lü; [2018]
    Nyckelord :;

    Sammanfattning : ABSTRACT  Aggregatibacter actinomycetemcomitans (Aa), is a gram-negative, facultative anaerobe, non-motile coccobacilli colonizing the human oral cavity and is strongly associated with localized aggressive periodontitis (LAP). Aa possesses several virulence mechanisms, among others; Lipopolysaccharide (LPS), an endotoxin found in the outer membrane of Aa and Leukotoxin (LtxA), an exotoxin attached to the bacterial cell surface or in outer membrane vesicles and which has been correlating with periodontal disease mostly. LÄS MER

  5. 4. Type IV secretion genes in cagE-negative Aggregatibacter actinomycetemcomitans serotype b

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Tandläkarutbildning

    Författare :Sarah Jasim; [2017]
    Nyckelord :Aggregatibacter actinomycetemcomitans;

    Sammanfattning : Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium that plays an important role in the development of aggressive periodontitis. The cagE gene, which encodes a putative exotoxin, has been found to be present in highly leukotoxic serotype b strains. LÄS MER

  7. 5. Effect of Aggregatibacter actinomycetemcomitans Leukotoxin on ATP Release through Pannexin Channels in Human Monocytes

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för odontologi

    Författare :Linnéa Bäck; Frykholm Jennie; [2016]
    Nyckelord :LtxA; ATP release; Aggregatibacter actinomycetemcomitans;

    Sammanfattning : Aggregatibacter actinomycetemcomitans is strongly associated with aggressive periodontitis and one of several virulence factors is a leukotoxin (LtxA). The toxin has a consequential impact on human leukocytes which leads to an interference with the host ́s defences due to a chain reaction involving activation and release of a pro-inflammatory cytokine; interleukin-1β (IL-1β). LÄS MER