Sökning: "ligand"
Visar resultat 1 - 5 av 130 uppsatser innehållade ordet ligand.
1. Characterization of diazepam binding inhibitor as a structure-function tool for human ɣ-aminobutyric acid-A receptors
Master-uppsats, KTH/ProteinvetenskapSammanfattning : Gammaaminosmörsyrareceptorer typ A (GABAAR) är pentameriska ligandstyrda kloridkanaler som uppvisar neurohämmande egenskaper. Därmed är de primära läkemedelsmål för flera ångestdämpande och lugnande läkemedel som används för att minska förekomsten av aktionspotential i neuroner. LÄS MER
2. Synthesis of Organo-Iron(II) Complexes Including N-Heterocyclic Carbene Ligation as Solar Cell Material.
Master-uppsats, Lunds universitet/Centrum för analys och syntesSammanfattning : The push-pull design has been shown to increase DSC performance through the introduction of electron-withdrawing groups and electron-donating groups, usually on opposite far ends of the sensitizer. The scope of this thesis was to synthesize several pre-N-heterocyclic carbene ligand analogs that are inspired by the push-pull design in an attempt to investigate their susceptibility to Fe(II) complexation. LÄS MER
3. Ligand-stimulated cleavage of PDGFR-beta
Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildningSammanfattning : Platelet-derived growth factor receptors (α and β) are included in the family of receptor tyrosine kinases (RTKs). The dimeric PDGF ligands bind to the PDGF receptors and this results in receptor dimerization, autophosphorylation, and thus activation. The autophosphorylated receptor dimer activates numerous signaling pathways. LÄS MER
4. Investigating ERβ chromatin binding and its potential interaction with LRH-1 in an ovarian context
Master-uppsats, KTH/ProteinvetenskapSammanfattning : Invasiv äggstockscancer anses vara en av de mest dödligaste gynekologiska maligniteterna. Granulosacelltumör i äggstocken är en sällsynt subtyp av äggstockstumör, som utgör 1–5% av alla äggstockstumörer. De kan kännetecknas av den långsamma tillväxthastigheten och produktionen av höga östrogennivåer. LÄS MER
5. Optimization of two high-performance size-exclusion chromatography methods with diode-array detection for protein quantification and purity assessment
Master-uppsats, Lunds universitet/Centrum för analys och syntesSammanfattning : Background: There is a need to develop methods of determining concentration and purity for two new affinity ligands, protein T and protein H, in order to ensure the quality of an industrial production of said proteins. Aims: To develop a High Performance Size Exclusion Chromatography, HPSEC, method to determine concentration and purity of protein T and to improve an existing HPSEC method for concentration and purity determination of protein H that show selectivity, display linearity between peak area and injection amount and give repeatable results. LÄS MER