Sökning: "lipid nanoparticles"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden lipid nanoparticles.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Författare :Elina Edidovica; [2024]
    Nyckelord :Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER

  3. 2. Comparison and optimization of extracellular vesicle (EV) capturing on functional thin films for their molecular profiling

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Prattakorn Metem; [2023]
    Nyckelord :extracellular vesicle; plasmonic nanohole array; atomic force microscopy; fluorescence analysis; extracellulära vesiklar; nanohålsuppsättning; atomkraftsmikroskopi; fluorescensanalys;

    Sammanfattning : Extracellular vesicles (EVs) are lipid bilayer encapsulated nanoparticles which have emerged as an excellent source of biomarkers for multiple diseases, including cancer. However, they are highly heterogeneous in their molecular compositions which remains a major challenge hindering the utilization of their biomarker potential. LÄS MER

  4. 3. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Owais Khalil; [2023]
    Nyckelord :Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Sammanfattning : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. LÄS MER

  5. 4. Affibody phage display selections for lipid nanoparticle and affibody-mediated transient CAR T-cell therapy

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Tasnim Yasin Idris; [2022]
    Nyckelord :affibody; phage display; in vitro selection; CD5; CD8; CD19; CAR T-cell therapy.;

    Sammanfattning : CAR T-cellbehandling är en immunterapi som har visat lovande resultat vid behandling av cancer. Trots det riktade immunsvaret som kan uppnås, betonar komplexiteten i tillverkningsprocessen och behandlingsproceduren det utrymme somm finns för förbättringar. LÄS MER

  7. 5. Exosomes and lipid nanoparticles - the future of targeted drug delivery

    Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Sara Lundberg; Emelia Karlsson; Hugo Dahlberg; Mathilda Glansk; Sara Larsson; Sofia Larsson; Karl Carlsson; [2020]
    Nyckelord :Exosomes; lipid nanoparticles; drug delivery;

    Sammanfattning : In this project an overview of how synthetic lipid nanoparticles and exosomes can be used for targeted drug delivery is compiled. The goal is to identify aspects that can be in favor for targeted drug delivery and the development of products at Cytiva. LÄS MER