Sökning: "mitochondrial DNA"

Visar resultat 16 - 20 av 41 uppsatser innehållade orden mitochondrial DNA.

  1. 16. Epigenetic Regulation of Mitochondrial DNA

    Kandidat-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Jennie Johansson; [2020]
    Nyckelord :Acetylation; Epigenetics; Heteroplasmy; Methylation; Mitochondrial haplotype; Mitochondrion; Non coding RNA; Phosphorylation;

    Sammanfattning : This mini-review investigates and compiles the latest knowledge regarding epigenetic changes on the mammalian mitochondrial DNA and its proteins. Methylation of the DNA, acetylation of the proteins and silencing of genes by short non-coding RNAs are the main epigenetic changes known today to affect mitochondrial DNA, mostly leading to repression. LÄS MER

  3. 17. Optimization of a multiplex ARMS-PCR for detection of the primary mutations causing Leber’s hereditary optic neuropath

    Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Författare :Klara Jäder; [2020]
    Nyckelord :Allele-specific PCR; LHON; Multiplex Polymerase Chain Reaction; mitochondrial DNA; single nucleotide polymorphism;

    Sammanfattning : Leber’s hereditary optic neuropathy (LHON) is a genetic disease that causes the patients to become blind, first in one eye and then the other, around the ages of 10-75 years. The disease is caused by mutations in the mitochondrial DNA, which disturbs the respiratory chain leading to the deterioration of the retinal ganglion cells. LÄS MER

  4. 18. Optimization of a Multiplex PCR-RFLP Method Used for Detection of Three Primary Mutations in Leber’s Hereditary Optic Neuropathy Patients

    Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Författare :Emilia Nord; [2020]
    Nyckelord :LHON; Restriction enzyme; Multiplex PCR; Mutation detection; Mitochondrial mutation;

    Sammanfattning : Leber’s hereditary optic neuropathy (LHON) is the most commonly inherited disease that causes blindness in one or both eyes, with a minimum prevalence of 1 in 31 000 in the northeast of England. What causes LHON is not fully known but three mitochondrial mutations, G3460A, G11778A, and T14484C, have been identified in over 95 % of all LHON patients. LÄS MER

  5. 19. Inheritance patterns of mitochondrial DNA in Drosophila paulistorum: substantial paternal transmission and the possible role of mitochondria in speciation

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för cell- och molekylärbiologi

    Författare :Jonathan Haars; [2019]
    Nyckelord :Drosophila Paulistorum; speciation; mitochondria; paternal transmission; paternal leakage; mtDNA; inheritance; hybridization;

    Sammanfattning : Direct studies of speciation are possible in the superspecies complex of Drosophila paulistorum, which consists of six different semispecies undergoing incipient speciation. Strict maternal inheritance of mitochondria is the most common pattern of mitochondrial inheritance in animals. LÄS MER

  7. 20. Identifying Mitochondrial Genomes in Draft Whole-Genome Shotgun Assemblies of Six Gymnosperm Species

    Kandidat-uppsats, Stockholms universitet/Matematiska institutionen

    Författare :Yrin Eldfjell; [2018]
    Nyckelord :machine-learning classification genome plant mitochondria svm contigs gymnosperm;

    Sammanfattning : Sequencing efforts for gymnosperm genomes typically focus on nuclear and chloroplast DNA, with only three complete mitochondrial genomes published as of 2017. The availability of additional mitochondrial genomes would aid biological and evolutionary understanding of gymnosperms. Identifying mtDNA from existing whole genome sequencing (WGS) data (i. LÄS MER