Sökning: "monoclonal antibodies"

Visar resultat 1 - 5 av 65 uppsatser innehållade orden monoclonal antibodies.

  1. 1. OPTIMIZATION OF CLONE SELECTION PLATFORM FOR PRODUCTION OF RECOMBINANT PROTEINS

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Basel Yousef; [2024]
    Nyckelord :;

    Sammanfattning : Background  Biologics are type of proteins that can be produced by expression in a foreign host for medical healthcare applications in humans. Monoclonal antibodies (mAbs) are type of biologics that are designed to specifically bind to one target, with a purpose to inhibit a certain molecule that could be associated with a disease process. LÄS MER

  3. 2. Establishment and Characterisation of new Immunoreagents for diagnosis of Ovarian cancer

    H-uppsats,

    Författare :Fanny Carlsson; [2023-04-19]
    Nyckelord :ovarian; cancer; monoclonal; antibodies; biomarkers; CARM1; PARPi; EZH2i;

    Sammanfattning : Ovarian cancer is the most lethal of all gynaecological cancers and it is often diagnosedat an advanced stage due to diffuse and only mild symptoms at early stages.Early detection is crucial to increase survival but high-grade serous ovarian cancer(HGSOC) often presents non-specific symptoms, such as loss of appetite, bloating ofabdomen and tiredness. LÄS MER

  4. 3. Vilka läkemedelsframsteg har förbättrat prognosen för HER2-positiv metastaserad bröstcancer? : En litteraturstudie

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Helena Hansson; [2023]
    Nyckelord :HER2; Bröstcancer; Läkemedel;

    Sammanfattning : Breast cancer is one of the deadliest forms of cancers in the world. About 15–30% of all breast cancers are HER2-positive, which involves overexpression of HER2-receptors on the surface of tumor cells. LÄS MER

  5. 4. ARIA-E vid behandling av Alzheimers sjukdom med monoklonala antikroppar

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Anna Hall; [2023]
    Nyckelord :Alzheimers sjukdom; aducanumab; lecanemab; gantanerumab; donanemab; ARIA-E; Apolipoprotein E4 ApoE4 ; cerebral amyloid angiopathy CAA ; screening; amyloid beta; monoklonala antikroppar;

    Sammanfattning : Introduction: Alzheimer's disease is a neurodegenerative disease that initially manifests itself primarily as impaired short-term memory and impaired language ability. The course of the disease is mainly due to an atrophy in the brain that can be attributed to the protein amyloid B and tau. LÄS MER

  7. 5. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Jonathan Efverström; [2023]
    Nyckelord :Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Sammanfattning : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. LÄS MER