Sökning: "morphological profiling"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden morphological profiling.

1. 1. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

   Master-uppsats, Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

   Författare :Erik Everett Palm; [2023]
   Nyckelord :bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

   Sammanfattning : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. LÄS MER

3. 2. Phenotypic profiling and drug screening in Rhabdomyosarcoma cell lines

   Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Laura Martina Lang; [2022]
   Nyckelord :Rhabdomyosarcoma; Phenotypic profiling; Phenotypic drug screening;

   Sammanfattning : Rhabdomyosarcoma (RMS) is a type of soft tissue sarcoma that mainly occurs in children. RMS can be divided into two subtypes embryonal (ERMS) and alveolar (ARMS). The ARMS subtype can be especially aggressive when a balanced chromosomal translocation is present. LÄS MER

4. 3. Epigenetic Profiling of Canine Brain

   Master-uppsats, KTH/Proteinvetenskap

   Författare :Roxanne Carlsson Norlin; [2022]
   Nyckelord :Dog; wolf; evolution; HiCap; enhancers; Hund; varg; evolution; HiCap; enhancers;

   Sammanfattning : Hundens domesticering är en av de äldsta och tros ha startats 35000 f.n. Under domesticeringen från varg till hund, har hunden utvecklat både morfologiska och beteendemässiga skillnader så som bredare snot, högre skallar och minskat risktagande. LÄS MER

5. 4. Representation learning for single cell morphological phenotyping

   Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Institutionen för fysik

   Författare :Andreas Nenner; [2022]
   Nyckelord :Deep learning; Image-based profiling;

   Sammanfattning : Preclinical research for developing new drugs is a long and expensive procedure. Experiments relying on image acquisition and analysis tend to be low throughput and use reporter systems that may influence the studied cells. LÄS MER

7. 5. Deep and Machine Learning on Imaging Flow Cytometry

   Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

   Författare :Xinyi Dai; [2022]
   Nyckelord :Imaging flow cytometry; image-based analysis; machine learning;

   Sammanfattning : Cell painting uses fluorescent agents to label the compositions or organelles of cells to evoke morphological profiling. Imaging flow cytometry (IFC) is a multi-channel imaging technique to acquire individual cell images, including the brightfield and multiple single fluorescence channels. LÄS MER