Sökning: "mutant studies"

Visar resultat 1 - 5 av 35 uppsatser innehållade orden mutant studies.

  1. 1. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Jonathan Efverström; [2023]
    Nyckelord :Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Sammanfattning : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. LÄS MER

  3. 2. Metacaspase type II : Biochemical studies of the activation anddegradation process of calcium-independentmetacaspase type II from Arabidopsis thaliana

    Master-uppsats, Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Författare :Anna Vikhagen; [2023]
    Nyckelord :;

    Sammanfattning : Proteases are found in all living kingdoms and are absolute essential for a functional cell to beable to break down peptide bonds. Metacaspases are proteases with the ability to cleave afterarginine and lysine residues. LÄS MER

  4. 3. Is the Expression of Hemolysin Co-regulated Protein (Hcp) Associated with Serum Resistance in Aggregatibacter aphrophilus?

    Master-uppsats, Umeå universitet/Tandläkarutbildning

    Författare :Clara Settlin; Selva Hot; [2023]
    Nyckelord :Aggregatibacter aphrophilus; hcp; T6SS; serum resistance;

    Sammanfattning : Abstract  Aggregatibacter aphrophilus, a Gram negative bacterium, found in the oral cavity, causing cerebral abscesses and infective endocarditis, has been shown to be serum resistant in previous studies. Bacterial secretion systems are important for bacteria as they transfer virulence factors into other bacteria or host cells as an attack. A. LÄS MER

  5. 4. Characterization of biological role of FKBP51-HSP90 protein-protein interactions in novel knock-in mouse model

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Shaoxun Xie; [2022]
    Nyckelord :FK506-binding protein 51kDa; heat shock protein 90kDa; glucocorticoid signaling pathway; dexamethasone; knock-in mouse model; FK506-bindande protein 51kDa; värmechockprotein 90kDa; glucocorticoiders signalvägar; dexamethasone; knock-in musmodell;

    Sammanfattning : Värmechockprotein 90 kDa (HSP90) bildar ett anmärkningsvärt komplicerat nätverk med en mängd olika cochaperones. Komplexet av FK506-bindande protein 51 kDa (FKBP51) och HSP90 förmedlar proteinveckning och funktion, främjar tau aggregation vid Alzheimers sjukdom och påverkar stressrelaterade störningar, fetma, typ två-diabetes, etc. LÄS MER

  7. 5. Effect of the cell-growth rate on the invasion and infection efficacy of Trypanosoma cruzi trypomastigotes, and the potential cell-to-cell transfer of the parasite

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Elisa Escabia Herrando; [2022]
    Nyckelord :Trypanosoma cruzi; infection kinetics; cell-to-cell infection; cell-growth rate;

    Sammanfattning : Recent studies proposed that mammalian cell lines with slower growth rates were infected more efficiently by Trypanosoma cruzi, and that cell-to-cell transmission could be occurring during infection. This open the question of whether host cell-growth rate is a cellular characteristic influencing Trypanosoma cruzi invasion and infection. LÄS MER