Sökning: "mutant"

Visar resultat 1 - 5 av 132 uppsatser innehållade ordet mutant.

  1. 1. Gene expression editing in myeloma cell lines using CRISPR/Cas9 technique

    Kandidat-uppsats, Uppsala universitet/Institutionen för medicinsk cellbiologi

    Författare :Wilma Wadman; [2023]
    Nyckelord :BMPR1A; BMPR2; bone morphogenetic protein; gene knockout; multiple myeloma;

    Sammanfattning : Multiple myeloma, or myeloma, is a bone marrow cancer which characterizes by uncontrolled proliferation of mutant plasma cells. It is a disease that claims many lives every year, mostly due to the absence of curative treatment. Finding a suitable treatment is therefor of great importance. LÄS MER

  3. 2. Increased catalytic activity of engineered next generation mutant aldolase

    Master-uppsats, Uppsala universitet/Biokemi

    Författare :Eda Sönmez; [2023]
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 3. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Jonathan Efverström; [2023]
    Nyckelord :Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

    Sammanfattning : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. LÄS MER

  5. 4. Recombinant expression and purification of sugar beet Phytoglobins in Escherichia Coli BL21 (DE3) including metabolic engineering of the heme biosynthesis

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Pennie Lindblom; Olivia Geel; [2023]
    Nyckelord :Phytoglobin; Heme; δ-ALA; qPCR; SDS-PAGE; Bacterial cultivation; Escherichia coli; BvPgb1.2; ÄKTA; Applied biochemistry; Biology and Life Sciences;

    Sammanfattning : The protein hemoglobin (Hb) is vital for us humans to ensure enough oxygen replacement in the body. Hb-resembling proteins also exist in plants, these are called phytoglobins (Pgbs). Pgbs are very interesting since they can play a considerable role in the development of blood substitutes and iron supplements for human use. LÄS MER

  7. 5. Metacaspase type II : Biochemical studies of the activation anddegradation process of calcium-independentmetacaspase type II from Arabidopsis thaliana

    Master-uppsats, Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Författare :Anna Vikhagen; [2023]
    Nyckelord :;

    Sammanfattning : Proteases are found in all living kingdoms and are absolute essential for a functional cell to beable to break down peptide bonds. Metacaspases are proteases with the ability to cleave afterarginine and lysine residues. LÄS MER