Sökning: "neuronal differentiation"

Visar resultat 1 - 5 av 9 uppsatser innehållade orden neuronal differentiation.

1. 1. PAMPaR: Parallel Analysis of miRNAs, Proteins and RNAs. Dynamic Profiles of miRNAs, mRNAs and Specific Proteins in Mouse Embryonic Stem Cells Differentiating into Neural Precursors

   Master-uppsats, KTH/Proteinvetenskap

   Författare :Amelie Carlström; [2023]
   Nyckelord :PAMPaR; SPARC; Proximity extension assay; Neuronal differentiation; Mouse embryonic stem cells; PAMPaR; SPARC; Proximity extension assay; Neuronal differentiering; embryonala musstamceller;

   Sammanfattning : MikroRNA-molekyler (miRNA) är viktiga icke-kodande RNA-molekyler för post-transkriptionell reglering av proteinkodande gener. De har även effekter på många cellulära processer såsom differentiering. De biosyntetiska reaktioner som skapar miRNA involverar proteiner som själva regleras av miRNA. LÄS MER

3. 2. Actin filaments as an indicator of impaired neuronal differentiation mediated by disruption of the retinoic acid signalling pathway

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Hanin Salloum; [2022]
   Nyckelord :Retinoic acid; actin; cytoskeleton; neural progenitor C17.2 cells; neuron; Coronin 1C; Cdc42 Cdc42 effector protein 4 gene ; Fn1 Fibronectin ; Wnt pathway.;

   Sammanfattning : Retinoic acid (RA) is a well-known neurodevelopmental signaling molecule. It is reported to induce effects on neurite formation in differentiating neurons and to interfere with the actin cytoskeleton. Therefore, this project aimed to investigate the mechanisms behind effects of RA on the actin cytoskeleton of developing neurons using the C17. LÄS MER

4. 3. Sex differences in neuronal differentiation of human stem cells

   Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Olga Doszyn; [2019]
   Nyckelord :stem cells; neural stem cells; embryonic stem cells; sex differences; neuronal differentiation;

   Sammanfattning : Sexual dimorphism has been long noted in human neurobiology, apparent most notably in sex-biased distribution of multiple neurological disorders or diseases, from autism spectrum disorder to Parkinson's disease. With the advances in molecular biology, genetics and epigenetics have come into focus as key players in sexually dimorphic neural development; and yet, many studies in the field of neuroscience overlook the importance of sex for the human brain. LÄS MER

5. 4. Characterization of NeuN expression in the mouse neuronal NSC-34 cell line using RT-qPCR, immunological staining and siRNA-mediated gene suppression

   Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

   Författare :Henrik Hallgren; [2019]
   Nyckelord :Rbfox-3; Neuronal Nucleus; motor neuron; differentiation; secondary injury;

   Sammanfattning : Background: Acute spinal trauma is followed by a secondary injury that causes additional damage to the tissue. The mouse neuronal hybrid cell line NSC-34 is planned for studies regarding this process, wherefore the cell line needed to be established in the laboratory and a proof-of-concept study needed to be performed. LÄS MER

7. 5. Effects of Different Laminins on Human Neural Progenitor Cells Cultured in 3D Electrospun Fibers

   Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

   Författare :Karl Vesterlund; [2019]
   Nyckelord :two-dimensional; three-dimensional; Alamar Blue; cell culture; drug development; extra-cellular matrix; electrospinning; immunocytochemistry; laminin; polycaprolactone; polymerase chain reaction; western blot; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences;

   Sammanfattning : A low success rate of drug candidates in clinical trials, and especially in brain research, motivates development of better screening models. Hence, in neuroscience and many other fields of Life Science, development of more physiological relevant experimental cell-based models is motivated. LÄS MER