Sökning: "nucleoside analog"

Hittade 2 uppsatser innehållade orden nucleoside analog.

  1. 1. Characterization of DNA Methylation in Giardia intestinalis

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Hassanat Agongo; [2021]
    Nyckelord :;

    Sammanfattning : Abstract G. intestinalis is an intestinal protozoan parasite that causes 180 million symptomatic diarrheacases (giardiasis) and more than 0.5 billion asymptomatic infections per year. Symptomaticinfections are usually treated with metronidazole (Flagyl). LÄS MER

  3. 2. Cloning, Expression and Purification of a Mutant Tomato Thymidine Kinase 1 for Crystallography

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Mohamad Nesrini; [2015]
    Nyckelord :protein expression; protein engineering; Azidothymidine; thymidine kinase; deoxyribonucleoside kinases; nucleosides; nucleoside analog; suicide gene therapy; tillämpad biokemi; applied biochemistry; BEVS.; Technology and Engineering; Chemistry;

    Sammanfattning : Thymidine kinase 1 from tomato (ToTK1) is a newly discovered deoxyribonucleoside kinase (dNK) that has been subject to study due to its in vitro and in vivo properties making it an interesting suicide gene candidate for the treatment of brain tumors. The ToTK1 phosphorylates the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (dThd). LÄS MER