Sökning: "pharmacodynamic"

Visar resultat 1 - 5 av 21 uppsatser innehållade ordet pharmacodynamic.

  1. 1. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Osama Qutishat; [2022]
    Nyckelord :Machine learning; pharmacometrics; Neural networks; pop-pk;

    Sammanfattning : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. LÄS MER

  3. 2. Design and analysis of pre-clinical experiments using a method combining multiple comparisons and modeling techniques for dose-response studies

    Master-uppsats, Göteborgs universitet/Institutionen för matematiska vetenskaper

    Författare :Avijit Singh; [2021-04-20]
    Nyckelord :pharmacodynamic modeling; dose–response relationship; significance level; multiple comparison procedure; optimal design; MCPMod; dose finding study;

    Sammanfattning : Abstract. Identifying and estimating the dose-response relationship between a compound and a pharmacological endpoint of interest is one of the most important and difficult goals in the preclinical stage of pharmaceutical drug development. LÄS MER

  4. 3. Mathematical model for the change of the protein profiles in urine during the bladder cancer development

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Xin Wen; [2021]
    Nyckelord :bladder cancer; immunotherapy; pharmacodynamic model;

    Sammanfattning : Most patients with bladder cancer are in the stage of non-muscle-invasive bladder cancer (NMIBC), while 30% of patients progress to the life-threatening muscle-invasive bladder cancer (MIBC) stage because of distant metastases. The selection of treatment options depends on the bladder cancer stage. LÄS MER

  5. 4. Linking Systems Models of Pharmacology with Behavioural Models of Adherence : A Feasibility Study

    Kandidat-uppsats, KTH/Medicinteknik och hälsosystem

    Författare :Simon Jenner; Dennis Amphan; [2020]
    Nyckelord :Pharmacology; Pharmacokinetics; Pharmacodynamics; PKPD-model; Diabetes; Adherence; Modelling; Feasibility; Farmakologi; Farmakokinetic; Farmakodynamik; PKPD-model; Diabetes; ̊Atlydnad; Modellering; Genomf ̈orbarhet;

    Sammanfattning : Pharmacokinetic (PK)- and pharmacodynamic (PD) modeling are useful tools whenassessing treatment effect. A patient’s adherence can potentially be rate-limiting, since it isthe first process in a chain of processes that determines treatment effect. LÄS MER

  7. 5. Development and comparison of bioanalytical methods to measure free analyte

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Alma Pihlblad; [2020]
    Nyckelord :Biotechnology; immunoassay; Gyrolab; ELISA; immunology; free analyte; overestimation; affinity; Avastin; bevacizumab; Lucentis; ranibizumab; VEGF; pharmacokinetic; pharmacodynamic;

    Sammanfattning : Free analyte is measured to be able to understand the pharmacological effects of a drug in the body, the binding to its ligand, and the effective drug level among other things. Thereby, it is important with correct measurements of free analyte, although it is not that easy to achieve since overestimations can occur. LÄS MER