Sökning: "pharmacokinetic-pharmacodynamic model"

Hittade 3 uppsatser innehållade orden pharmacokinetic-pharmacodynamic model.

1. 1. An Investigation of Semantic Interoperability with EHR systems for Precision Dosing

   Master-uppsats, KTH/Medicinteknik och hälsosystem

   Författare :Jovia Namugerwa Mukwaya; [2020]
   Nyckelord :precision dosing; ontology; semantic interoperability; precision medicine;

   Sammanfattning : In healthcare, vulnerable populations that are using medications with a narrow therapeutic index and wide interpatient PK/PD (pharmacokinetic/pharmacodynamic modelling) variability are increasing. As such, variable dosage regimens may result in severe therapeutic failures or adverse drug reactions (ADR). LÄS MER

3. 2. Standard two-stage and Nonlinear mixed effect modelling for determination of cell-to-cell variation of transport parameters in Saccharomyces cerevisiae

   Master-uppsats, Reglerteknik; Tekniska högskolan

   Författare :David Janzén; [2012]
   Nyckelord :Systems biology; mathematical modelling; profile likelihood; cell-to-cell variation; STS; NONMEM; Saccharomyces cerevisiae;

   Sammanfattning : The interest for cell-to-cell variation has in recent years increased in a steady pace. Several studies have shown that a large portion of the observed variation in the nature originates from the fact that all biochemical reactions are in some respect stochastic. LÄS MER

4. 3. A fuzzy logic controller for intestinal levodopa infusion in Parkinson’s disease

   Kandidat-uppsats, Datateknik

   Författare :Xiaowen Jiang; [2010]
   Nyckelord :Parkinson Disease; fuzzy controller; pharmacokinetic-pharmacodynamic model; levodopa; infusion; dose titration;

   Sammanfattning : The aim of this work is to evaluate the fuzzy system for different types of patients for levodopa infusion in Parkinson Disease based on simulation experiments using the pharmacokinetic-pharmacodynamic model. Fuzzy system is to control patient’s condition by adjusting the value of flow rate, and it must be effective on three types of patients, there are three different types of patients, including sensitive, typical and tolerant patient; the sensitive patients are very sensitive to drug dosage, but the tolerant patients are resistant to drug dose, so it is important for controller to deal with dose increment and decrement to adapt different types of patients, such as sensitive and tolerant patients. LÄS MER