Sökning: "physiologically-based pharmacokinetics"

Hittade 4 uppsatser innehållade orden physiologically-based pharmacokinetics.

  1. 1. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

    Kandidat-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Rosa Kafey; [2022]
    Nyckelord :PBPK; MODELLS;

    Sammanfattning : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. LÄS MER

  3. 2. Pharmacokinetic changes of meropenem in sepsis patients: A Comparative Review

    Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaci

    Författare :Rami Osman Abubaker; [2022]
    Nyckelord :;

    Sammanfattning : Background: Sepsis is a life-threatening organ dysfunction occurring during infections. Meropenem is a hydrophilic β-lactam carbapenem antibiotic. Its pharmacokinetic parameters are expected to change due to sepsis-induced physiological alterations and will thus require altered dosing strategies for optimal treatment of sepsis patients. LÄS MER

  4. 3. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Albin Leding; [2021]
    Nyckelord :Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

    Sammanfattning : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. LÄS MER

  5. 4. Physiological ranges and variability in organ blood flow in laboratory animals

    Kandidat-uppsats, SLU/Dept. of Biomedical Sciences and Veterinary Public Health

    Författare :Camilla Anger; [2014]
    Nyckelord :organblodflöden; laboratoriedjur; farmakokinetik; regionala blodflöden; scaling; fysiologiska parametrar; organ blood flow; cardiac output; laboratory animals; physiologically based pharmacokinetics; microspheres; physiological parameters;

    Sammanfattning : BACKGROUND: Organ blood flow rates are useful in allometric scaling and for the application of Physiologically Based Pharmacokinetic Modeling (PBPK). These models are typically used for extrapolating pharmacokinetic data across different species, which has important applications in drug discovery and safety assessment. LÄS MER