Sökning: "population pharmacokinetics"

Visar resultat 1 - 5 av 11 uppsatser innehållade orden population pharmacokinetics.

  1. 1. Towards individualised anaesthesia: A comparison between target-controlled infusion and closed-loop control

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Institutionen för reglerteknik

    Författare :Amanda Gustafsson; [2023]
    Nyckelord :Technology and Engineering;

    Sammanfattning : Individualised healthcare is the future of medicine, due to the so called inter-patient variability. The inter-patient variability involves differences in the drug response between different patients. The effect of a drug can usually be divided into pharmacokinetics (PK) and pharmacodynamics (PD). LÄS MER

  3. 2. Population Pharmacokinetics of Linezolid for Optimization of the Treatment for Multidrug Resistant Tuberculosis

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Viktor Hansen; [2022]
    Nyckelord :tuberculosis; drug resistance; pharmacometrics; pharmacokinetics; pop-pk; south africa; non linear mixed effects modelling; nlme;

    Sammanfattning : Tuberculosis is one the leading causes of death globally and was before the COVID-19 pandemic the leading cause of death from a single infectious agent. Developing active tuberculosis is life threatening and therefore is the rise of drug-resistant tuberculosis alarming as this risk causing current treatments to become ineffective. LÄS MER

  4. 3. Development of artificial neural networks for the prediction of outlying and influential individuals from pharmacokinetic and pharmacodynamic models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Osama Qutishat; [2022]
    Nyckelord :Machine learning; pharmacometrics; Neural networks; pop-pk;

    Sammanfattning : Nonlinear Mixed effect models are often used to describe population pharmacokinetics (PK) and Pharmacodynamics (PD) and play an important part of drug development both from regulatory and industry point of view. However, they can be time consuming and computationally expensive to develop. LÄS MER

  5. 4. Populations PK-modellering för IR-formulering av Gliclazid

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Haneen Hussein; [2022]
    Nyckelord :Typ 2-diabetes; Gliclazid; Populations PK-modellering; Monolix;

    Sammanfattning : Introduction: Type-2 diabetes is one of the most common metabolic diseases characterized by elevated blood sugar levels in the body. The disease is caused by lost insulin sensitivity and insufficient insulin production, which leads to an increase in sugar levels in the blood. LÄS MER

  7. 5. Automatic Development of Pharmacokinetic Structural Models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Alzahra Hamdan; [2022]
    Nyckelord :pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Sammanfattning : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. LÄS MER