Sökning: "protease inhibitor"

Visar resultat 1 - 5 av 14 uppsatser innehållade orden protease inhibitor.

  1. 1. In Vitro Assessment of Novel Compounds as Potential Pan-Coronavirus Therapeutics in SARS-CoV-2 and In Vitro Assessment of a Pan-Flavivirus Compound in Zika Virus

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Julia Berger; [2022]
    Nyckelord :Human coronavirus; active protease inhibitors; drug discovery; 3CLpro; Zika virus; flavivirus inhibitor; NS2B-NS3;

    Sammanfattning : Through the SARS-CoV-2 pandemic, it has become clear that the development of antivirals is essential for the health and wellbeing of the population. In this study, novel active site protease inhibitors against SARS-CoV-2 were tested for their inhibitory activity against the viral 3-Chymotrypsin like protease through the means of FRET based enzymatic assays. LÄS MER

  3. 2. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Elin Öberg; [2022]
    Nyckelord :x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Sammanfattning : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. LÄS MER

  4. 3. Drug repositioning of protease inhibitors in combinational therapy as a treatment forCOVID-19

    Uppsats för yrkesexamina på grundnivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Max Malmberg; [2021]
    Nyckelord :COVID-19; protease inhibitor; combinational treatment;

    Sammanfattning : There is currently no standardized treatment of COVID-19. Despite several vaccines being deployed, the need for an effective treatment in hospitalized patients is heavily sought after. LÄS MER

  5. 4. Kinetic studies of carrier conjugated protease inhibitors

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för kemi - BMC

    Författare :Enrique Argenis López Olvera; [2019]
    Nyckelord :Proteases inhibitors; bioconjugates; enzyme kinetics; inhibition;

    Sammanfattning : Conjugates of soybean trypsin inhibitor (SBTI) and potato serine protease inhibitor (PSPI) immobilized on metal oxide particles of ~100nm diameter were prepared. Inhibition of trypsin hydrolysis of BAPA by these conjugates was measured and enzyme kinetics constants kcat, KM, kcat/KM and ki were determined. LÄS MER

  7. 5. Analysis of active botulinumtoxin in biological matrices for applications in veterinary botulism outbreaks

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Ida Karlsson; [2018]
    Nyckelord :;

    Sammanfattning : Botulinum neurotoxins (BoNTs), produced by the bacteria Clostridium botulinum,are the deadliest toxins known to mankind, causing the disease botulism. Thecurrently golden standard for detection of active BoNTs is the mouse bioassay(MBA). The ethical concern of the MBA has however encouraged the development ofother methods for detecting BoNTs. LÄS MER