Sökning: "protein crystallization"

Visar resultat 1 - 5 av 28 uppsatser innehållade orden protein crystallization.

  1. 1. Crystallization, optimization, and crystal structure determination of ligands in complex with galectin-8N

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :George Larsson; [2022]
    Nyckelord :Biochemistry; Structural Biochemistry; Galectin-8; Protein Crystallization; Chemistry;

    Sammanfattning : This thesis focuses on the protein “galectin-8N” which is a lectin protein that takes part in several physiological functions such as inflammation, autophagy, cell migration, and more. The project has three objectives: to observe and increase the reproducibility of crystallization of two variants (wildtype and mutant) of the human protein galectin-8N and to analyze the binding site when three different novel ligands are each inserted. LÄS MER

  3. 2. Effect of the Cooling Rate and the Surface Film Composition on the Colloidal Stability of Whey Protein Based Emulsions of Triacylglycerols

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Charlotte Schüler; [2022]
    Nyckelord :Emulsion technology; Fat crystallization; Emulsified triglycerides; Colloid science; Food technology; Agriculture and Food Sciences; Technology and Engineering;

    Sammanfattning : The goal of this project was to investigate the effect and interplay of formulation and processing parameters on the colloidal stability of emulsified triacylglycerols from a product quality perspective. Different methods to quantify and monitor this effect over time were evaluated. LÄS MER

  4. 3. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Elin Öberg; [2022]
    Nyckelord :x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Sammanfattning : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. LÄS MER

  5. 4. Structure-based design of novel pharmacological tools for the A3 adenosine G protein-coupled receptor

    Master-uppsats, Uppsala universitet/Institutionen för läkemedelskemi

    Författare :Ashish Tamhankar; [2021]
    Nyckelord :;

    Sammanfattning : Adenosine receptors (ARs) are a family belonging to the GPCR superfamily, involved with multiple physiological processes and widely distributed throughout the body. In this study, we focus on the A3 AR due to its vast scale applications in various pathophysiological conditions such as inflammation, pain, allergic asthma, and cancer chemotherapy. LÄS MER

  7. 5. Purification, activity assays and crystallization of GtCel45A - a small cellulase enzyme from the brown-rot fungus Gloeophyllum trabeum expressed in Aspergillus nidulans

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Strukturbiologi

    Författare :Louise Fitkin; [2021]
    Nyckelord :;

    Sammanfattning : Cellulose is the most abundant polymer on earth. It is one of the main components in lignocellulosic biomass, which has great potential as a renewable energy source. To utilize the biomass, for instance in biofuel production, cellulose needs to be degraded. LÄS MER