Sökning: "proteome"

Visar resultat 1 - 5 av 26 uppsatser innehållade ordet proteome.

  1. 1. Profiling the Blood Proteome in Autoimmune Disease Using Proximity Extension Assay

    Master-uppsats, KTH/Proteinvetenskap

    Författare :Julia Asp; [2023]
    Nyckelord :Plasma proteomics; proximity extension assay; autoimmune disease; differential expression; machine learning; biomarkers; Plasma proteomik; proximity extension assay; autoimmuna sjukdomar; differentiellt proteinuttryck; maskininlärning; biomarkörer;

    Sammanfattning : Autoimmuna sjukdomar är en samling komplexa, kroniska, inflammatoriska sjukdomstillstånd som kännetecknas av dysreglering av immunsystemet, vilket resulterar i inflammation och skada av vävnader, celler och organ. Dessa sjukdomar har en betydande inverkan på individens livskvalitet och bidrar ofta till ökad dödsrisk där komorbiditeter föreligger. LÄS MER

  3. 2. Evaluating targeted combination therapies in EGFR wild-type non-small-cell lung cancer using mass spectrometry-based proteomics

    Master-uppsats, Lunds universitet/Institutionen för immunteknologi

    Författare :Johan Thorsson; [2023]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Survival for non-small cell lung cancer (NSCLC) patients has been significantly improved by epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in patients with EGFR mutations. However, certain subpopulations of NSCLC patients with EGFR wild-type (wt) status have been shown to also respond to EGFR-TKIs. LÄS MER

  4. 3. Biologically informed neural network for subphenotype classification in septic AKI

    Master-uppsats, Lunds universitet/Avdelningen för Biomedicinsk teknik

    Författare :Erik Hartman; [2022]
    Nyckelord :Machine learning; neural networks; proteomics; sepsis; AKI; Technology and Engineering;

    Sammanfattning : Sepsis is a life threatening condition where the body’s reaction to an infection results in a dysregulated immune response - ultimately causing damage to tissues and organs. The syndrome is diverse, both in underlying biology, disease manifestation and severity, and is therefore divided into endotypes and further into subphenotypes. LÄS MER

  5. 4. Classification of sequence tags from tandem mass spectrometry spectra using machine learning models

    Master-uppsats, Lunds universitet/Examensarbeten i bioinformatik

    Författare :Júlia Ortís Sunyer; [2022]
    Nyckelord :Biology and Life Sciences;

    Sammanfattning : Motivation: Proteomics is the large-scale study of all the proteins found in a cell, tissue or organism. In the last few years, and thanks to the development of mass spectrometry and bioinformatics, proteomics has led the research in several fields, ranging from medicine to agriculture. LÄS MER

  7. 5. Expanding the application of a novel proteomics tool for drug target and mechanism identification

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Linnéa Yuan Andersson; [2022]
    Nyckelord :;

    Sammanfattning : In drug discovery and development, characterization of the drug targets and mechanisms of action is an essential step. ProTargetMiner is a publicly available proteome signature library of anticancer molecules and its automated bioinformatics platform can be used for drug target and mechanism deconvolution. LÄS MER