Sökning: "sialic acids"

Hittade 4 uppsatser innehållade orden sialic acids.

  1. 1. Exploring Regioselective 5N-acylation of Neuraminic acid

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Simon Hans Lilje; [2022]
    Nyckelord :acylation; amide; antibacterial drugs; regioselective deprotection; sialic acid; organic chemistry; Chemistry;

    Sammanfattning : In this project, a regioselective method to deprotect and acylate the amide on C5 of sialic acid is explored. Sialic acid is one of the most complex monosaccharides and is an important ligand in many higher organisms in intercellular cell communication. The most prominent example is related to the immune system. LÄS MER

  3. 2. Synthesis of the sialic acid 9-C derivative with an amino group replacing the OH-group.

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Hanna Malmquist; [2018]
    Nyckelord :organic chemistry; sialic acids; antibiotics; organic synthesis; organisk kemi; Chemistry;

    Sammanfattning : Almost everyone is aware of the big problem with increasing antibiotic resistance among bacteria and the importance and need of developing new antibiotics. This bachelor thesis is a part of one such project with the aim to find new possible antibiotics. A promising candidate is a derivative of the sialic acids. LÄS MER

  4. 3. Comparison of two HPLC columns: An attempt to improve analysis of carbohydrate-deficient transferrin

    Kandidat-uppsats, Uppsala universitet/Institutionen för kvinnors och barns hälsa

    Författare :Ida Engström; [2018]
    Nyckelord :Reprospher; liquid chromatography; ion exchange chromatography; CDT; gradient elution;

    Sammanfattning : 1ABSTRACTCarbohydrate-deficient transferrin (CDT) is a biomarker for excessive and long-running intake of alcohol. It is a form of transferrin called disialotransferrin that under normal circumstances is <2 % of total transferrin in human blood. An increase is seen when alcohol consumption exceeds450 g per week. LÄS MER

  5. 4. Sialic acids derivatised at C-4 as ligands for bacterial SSS transport proteins

    Master-uppsats, Lunds universitet/Centrum för analys och syntes; Lunds universitet/Kemiska institutionen

    Författare :Klara Hammarstrand; [2017]
    Nyckelord :KOK820 organic chemistry; medicinal chemistry; drug development; method development; antibiotics; organic synthesis; Chemistry;

    Sammanfattning : This master thesis project focuses on establishing a synthetic method with the prospect of developing new antibacterial agents. Due to the increment of resistant strains of bacteria throughout the world, this area of research is well motivated. LÄS MER