Sökning: "site-directed mutagenesis"

Visar resultat 1 - 5 av 14 uppsatser innehållade orden site-directed mutagenesis.

  1. 1. Killer action of Spok homologue in Fusarium vanattenii : Investigation through site directed mutagenesis

    Kandidat-uppsats, Uppsala universitet/Institutionen för organismbiologi; Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Samuel Jorayev; [2023]
    Nyckelord :Spok genes; FuSpok; Meiotic Driver; Fusarium; transposons;

    Sammanfattning : The Spok genes are a group of selfish genetic elements in the fungus Podespora anserina which kills spores lacking them. These Spoks function through a toxin and resistance domain. Homologues of these have been found across other species such as in the Fusarium genus. LÄS MER

  3. 2. Structure-based design of novel pharmacological tools for the A3 adenosine G protein-coupled receptor

    Master-uppsats, Uppsala universitet/Institutionen för läkemedelskemi

    Författare :Ashish Tamhankar; [2021]
    Nyckelord :;

    Sammanfattning : Adenosine receptors (ARs) are a family belonging to the GPCR superfamily, involved with multiple physiological processes and widely distributed throughout the body. In this study, we focus on the A3 AR due to its vast scale applications in various pathophysiological conditions such as inflammation, pain, allergic asthma, and cancer chemotherapy. LÄS MER

  4. 3. Characterization of DNA binding of the two zinc finger domains of transcription factor zBED6

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Alexander Taubert; [2019]
    Nyckelord :transcription factor; zinc finger; zBED6;

    Sammanfattning : The zinc finger protein, zBED6, is a transcriptional regulator of IGF2 along with hundreds of other genes relating to development and growth. Studies on the growth of commercially bred pigs discovered a single nucleotide substitution in the third intron of IGF2 which disrupts the binding of zBED6 and is responsible for the three-fold upregulation of IGF2 in skeletal muscle. LÄS MER

  5. 4. Probing the G protein selectivity of FR900359 by means of molecular modeling and site directed mutagenesis

    Uppsats för yrkesexamina på avancerad nivå, Umeå universitet/Farmakologi

    Författare :Michelle Malmberg; [2017]
    Nyckelord :GPCRs; G protein; FR900359; YM-254890; Molecular modeling;

    Sammanfattning : .... LÄS MER

  7. 5. Production and Characterization of Recombinant Amelogenin Phosphorylation Mimics

    Master-uppsats, Lunds universitet/Tillämpad biokemi

    Författare :Krishma Eloise Jean Baptiste; [2016]
    Nyckelord :tillämpad biokemi; applied biochemistry; Technology and Engineering;

    Sammanfattning : Amelogenin is an extracellular matrix protein which has an important role to play in enamel formation during tooth development. The need for amelogenin for research purposes in order to be utilized for its many potential applications have resulted in the rise of the production of recombinant amelogenin. LÄS MER