Sökning: "small angle X-ray scattering"

Visar resultat 1 - 5 av 23 uppsatser innehållade orden small angle X-ray scattering.

  1. 1. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Samuel Eriksson Lidbrink; [2023]
    Nyckelord :AlphaFold; AlphaFold2; SAXS; protein conformational ensembles; machine learning; protein conformations; reweighting; SAXS; AlphaFold; AlphaFold2; proteinkonformationsensembler; maskininlärning; proteinkonformationer; omviktning;

    Sammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER

  2. 2. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Javier Lagares Martín; [2023]
    Nyckelord :Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. LÄS MER

  3. 3. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Owais Khalil; [2023]
    Nyckelord :Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Sammanfattning : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. LÄS MER

  4. 4. Green Coacervates for Pharma and Food

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Izabella Imets; Andreas Vallin; [2022]
    Nyckelord :MSc; coacervate; biosurfactant; biopolymer; SAXS; DLS; elliposometry; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Anionic biosurfactant-cationic biopolymer systems were investigated to identify and characterize a coacervation window. The characterization of the systems was performed with dynamic light scattering, small angle x-ray scattering and in-situ ellipsometry. LÄS MER

  5. 5. Development and characterization of an eco-friendly cosmeceutical formulation with optimal performance.

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Marshall Ringisayi Machingauta; [2022]
    Nyckelord :Emulsifier; lamellar liquid crystals; o w emulsions; phosphatidylcholine; small-angle X-ray scattering SAXS ; shea butter; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Cosmetic innovations are about finding high performing creative solutions that deliver into the consumer trends. The consumer trend within the cosmetic industry is currently driving a growing demand for more clean, natural skin care products with sustainable credentials. LÄS MER