Sökning: "structural conformation"

Visar resultat 1 - 5 av 11 uppsatser innehållade orden structural conformation.

  1. 1. Omvärldsbevakning inom folkbiblioteksverksamhet : Utformning och utvecklingsmöjligheter

    Kandidat-uppsats, Högskolan i Borås/Akademin för bibliotek, information, pedagogik och IT

    Författare :Emelie Fischer; Jeanette Sörbom; [2022]
    Nyckelord :Omvärldsbevakning; Folkbiblioteksverksamhet; Informationspraktik; Informationssökning; Informationsbeetende;

    Sammanfattning : This bachelor’s thesis aims to examine the librarians' Competitive Intelligence (CI) practices and their views on the matter. Today, easy access to information makes greater demands on librarians’ and users’ knowledge regarding source criticism. LÄS MER

  3. 2. Evaluating a coarse-grained IDP-model for structure and dynamics

    Kandidat-uppsats, Lunds universitet/Biofysikalisk kemi

    Författare :Louise Kalander; [2021]
    Nyckelord :IDP; Intrinsically disordered proteins; Histatin 5; Simulation; Biophysical chemistry; Chemistry;

    Sammanfattning : In this study a coarse-grained model of intrinsically disordered proteins (IDPs) is evaluated to determine whether the model is suitable to use for analyzing the structure and dynamics of IDPs. IDPs are proteins that lack a stable tertiary structure which gives them a flexible structure. LÄS MER

  4. 3. Structural basis of modulation by pH and calcium in a ligand-gated ion channel

    Master-uppsats, KTH/Genteknologi

    Författare :Olivia Andén; [2021]
    Nyckelord :Pentameric ligand-gated ion channels; bacterial homolog; protein expression; protein purification; cryo-electron microscopy; data processing; protein structure; Pentamerisk ligandstyrd jonkanal; bakteriell homolog; proteinexpression; proteinrening; kryo-elektronmikroskopi;

    Sammanfattning : Pentameriska ligandstyrda jonkanaler (pLGICs) är avgörande för omvandlingen av kemisk till elektrisk signalöverföring i djurs nervsystem. Dysfunktion i dessa kanaler har visat sig vara kopplad till flera sjukdomar inklusive epilepsi, schizofreni, Alzheimers och autism, vilket gör dem till en måltavla för en mängd olika läkemedel. LÄS MER

  5. 4. Clustering approaches for extracting structural determinants of enzyme active sites

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Ismini - Christina Stamatelou; [2020]
    Nyckelord :Structural bioinformatics; enzyme; active site; glycogen phosphorylase; clustering; rotamer; conformation; k-means; clara;

    Sammanfattning : The study of enzyme binding sites is an essential but rather demanding process of increased complexity since the amino acids lining these areas are not rigid. At the same time, the minimization of side effects and the specificity of new ligands is a great challenge in the structure-based drug design approach. LÄS MER

  7. 5. Determination of specificity and affinity of the Lactose permease (LacY) protein of Escherichia coli through application of molecular dynamics simulation

    Master-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Stuart Lutimba; [2018]
    Nyckelord :;

    Sammanfattning : Proteins are essential in all living organisms. They are involved in various critical activities and are also structural components of cells and tissues. LÄS MER