Sökning: "structure eludication"

Hittade 1 uppsats innehållade orden structure eludication.

  1. 1. Evaluation of a UPLC-MS method using 18O-labelled water for the identification of hydrolytic degradants of drug substances

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen för analytisk farmaceutisk kemi

    Författare :Viktor Kjellberg; [2015]
    Nyckelord :hydrolysis; degradation; degradants; 18O; 18O-water; liquid chromatography; mass spectrometry; analytical chemistry; structure eludication;

    Sammanfattning : In this master’s thesis the hydrolytic degradation in 18O-water solutions of six drug substances has been studied. The aim was to develop a mass spectrometric method for easier identification of degradants, since hydrolysis in 18O-water will generate degradants with higher mass compared with hydrolysis in regular water. LÄS MER