Sökning: "structure-based drug design"

Hittade 4 uppsatser innehållade orden structure-based drug design.

  1. 1. Structure-based design of new antiviral substances against the Venezuelan equine encephalitis virus

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Elin Öberg; [2022]
    Nyckelord :x-ray crystallography; protein crystallization; Venezuelan equine encephalitis virus; structure-based drug design; applied biochemistry; Technology and Engineering;

    Sammanfattning : The Venezuelan equine encephalitis virus (VEEV) is a highly infectious alphavirus responsible for severe outbreaks and epidemics in the Americas. The nonstructural protein 2 (nsP2) cysteine protease plays a fundamental role in the VEEV replication process, and is therefore, an attractive drug target for structure-based drug design using x-ray crystallography. LÄS MER

  3. 2. Clustering approaches for extracting structural determinants of enzyme active sites

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Ismini - Christina Stamatelou; [2020]
    Nyckelord :Structural bioinformatics; enzyme; active site; glycogen phosphorylase; clustering; rotamer; conformation; k-means; clara;

    Sammanfattning : The study of enzyme binding sites is an essential but rather demanding process of increased complexity since the amino acids lining these areas are not rigid. At the same time, the minimization of side effects and the specificity of new ligands is a great challenge in the structure-based drug design approach. LÄS MER

  4. 3. Strukturella och funktionella studier av fyra enzymer involverade i cellväggsbiosyntes hos Mycobacterium tuberculosis

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Joanna Källgren; [2015]
    Nyckelord :Mycobacterium tuberculosis; structure-based drug design; enzymes; cloning; expression; purification; crystallization;

    Sammanfattning : The pathogenic bacterium Mycobacterium tuberculosis (Mt) is the causative agent of tuberculosis, a widespread and fatal infectious disease. Today, treatment against tuberculosis involves a combination of drugs, which need to be taken for at least six months and which often causes severe side effects. LÄS MER

  5. 4. Synthesis of Insulin-Regulated Aminopeptidase (IRAP) inhibitors

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi; Uppsala universitet/Avdelningen för organisk farmaceutisk kemi

    Författare :Faith Agalo; [2015]
    Nyckelord :Non-peptide IRAP inhibitors; microwave synthesis; cognitive imparement; cognitive enhancers; Alzheimer s disease; spirooxindole dihydroquinazolinone; Angiotensin IV;

    Sammanfattning : The need for alternative cognitive enhancers has risen due to the fact that clinical trial results of the drugs currently approved for treating these disorders have not been satisfactory. IRAP has become a possible drug target for treating cognitive impairment brought about by Alzheimer’s disease, head trauma or cerebral ischemia, among others. LÄS MER