Sökning: "subvisible particles"

Hittade 2 uppsatser innehållade orden subvisible particles.

1. 1. Methods to study device induced aggregation of proteins

   Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

   Författare :Marie Therese von Wowern; [2023]
   Nyckelord :protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

   Sammanfattning : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. LÄS MER

3. 2. Pharmaceutical Quality and Syringeabilityof Pre-filled Syringes : An explorative study on the effect of different syringe barrel andplunger combinations on a proteinaceous pharmaceutical.

   Master-uppsats, KTH/Skolan för kemi, bioteknologi och hälsa (CBH)

   Författare :Emma Sevegran; [2020]
   Nyckelord :Pre-filled syringes; protein aggregation; break loose; gliding force; pharmaceutical quality; subvisible particles; silicone oil; barrel; plunger;

   Sammanfattning : 4AbstractA pre-filled syringe consists of a number of different components and materials e.g. glass, polymer and silicone oil, which will, in various degrees, interact with the pharmaceutical protein and excipients contained within. LÄS MER