Sökning: "synergistic combination"

Visar resultat 1 - 5 av 34 uppsatser innehållade orden synergistic combination.

  1. 1. Apoptosis induction in breast cancer cells after radiotherapy and potential radiosensitizers

    Master-uppsats,

    Författare :Klara Simonsson; [2023-06-27]
    Nyckelord :Medical physics; Breast cancer cells; radiotherapy; systemic therapy; combination therapy; apoptosis; BH3 profiling; flow cytometry;

    Sammanfattning : Background. Today breast cancer is the foremost cancer death type amongst women around the world. At present some of the toughest challenges in the clinic is recurrent, radioresistant breast cancer, and metastatic breast cancer where low cure rates are observed after surgery and radiotherapy. LÄS MER

  3. 2. Establishment and Characterisation of new Immunoreagents for diagnosis of Ovarian cancer

    H-uppsats,

    Författare :Fanny Carlsson; [2023-04-19]
    Nyckelord :ovarian; cancer; monoclonal; antibodies; biomarkers; CARM1; PARPi; EZH2i;

    Sammanfattning : Ovarian cancer is the most lethal of all gynaecological cancers and it is often diagnosedat an advanced stage due to diffuse and only mild symptoms at early stages.Early detection is crucial to increase survival but high-grade serous ovarian cancer(HGSOC) often presents non-specific symptoms, such as loss of appetite, bloating ofabdomen and tiredness. LÄS MER

  4. 3. Combining Cell Painting, Gene Expression and Structure-Activity Data for Mechanism of Action Prediction

    Master-uppsats, Uppsala universitet/Nationellt resurscentrum för biologi och bioteknik

    Författare :Erik Everett Palm; [2023]
    Nyckelord :bioinformatics; deep learning; machine learning; joint model; tabular data; image data;

    Sammanfattning : The rapid progress in high-throughput omics methods and high-resolution morphological profiling, coupled with the significant advances in machine learning (ML) and deep learning (DL), has opened new avenues for tackling the notoriously difficult problem of predicting the Mechanism of Action (MoA) for a drug of clinical interest. Understanding a drug's MoA can enrich our knowledge of its biological activity, shed light on potential side effects, and serve as a predictor of clinical success. LÄS MER

  5. 4. Vilka läkemedelsframsteg har förbättrat prognosen för HER2-positiv metastaserad bröstcancer? : En litteraturstudie

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Helena Hansson; [2023]
    Nyckelord :HER2; Bröstcancer; Läkemedel;

    Sammanfattning : Breast cancer is one of the deadliest forms of cancers in the world. About 15–30% of all breast cancers are HER2-positive, which involves overexpression of HER2-receptors on the surface of tumor cells. LÄS MER

  7. 5. Johannesört – effektiv behandling vid infektioner? : Medicinalväxten Hypericum perforatum L. och dess antibakteriella aktivitet mot multiresistenta Staphylococcus aureus 

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Amelie Carlsson; [2023]
    Nyckelord :antibakteriell aktivitet; buljongspädningsmetoden; antibiotikaresistens; Hypericum perforatum L.; Staphylococcus aureus; in vitro;

    Sammanfattning : Antibiotic resistance is a rapidly increasing and serious global problem, with infectious diseases currently being the second leading cause of death worldwide. The World Health Organization (WHO) has estimated that 700,000 people worldwide die each year as a result of antibiotic resistance, and this number is projected to rise to 10 million per year by 2050 if no action is taken. LÄS MER