Sökning: "tricarboxylic acid TCA cycle"

Hittade 4 uppsatser innehållade orden tricarboxylic acid TCA cycle.

  1. 1. Impact of PFAS exposure on the fecal metabolome

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Lisa Johansson; [2022]
    Nyckelord :Gut metabolites; LC-qTOF-MS; PFAS;

    Sammanfattning : The human gut microbiota plays a crucial role in human health and therefore imbalances in gut microbiota functioning can lead to the development of metabolic disorders. Short-chain fatty acids (SCFA), tricarboxylic acid (TCA) cycle metabolites, bile acids (BA) and other metabolites are the essential compounds for the metabolome. LÄS MER

  3. 2. Impact of polychlorinated biphenyl- and organochlorine pesticide exposure on faecal metabolome

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Maja Näsman; [2022]
    Nyckelord :Gut microbiota; polychlorinated biphenyls; organochlorine pesticides; tricarboxylic acid cycle; bile acids; LC-qTOF-MS.;

    Sammanfattning : The gut microbiota plays a major part in maintaining the health of a human host. Countless of crucial functions in the body, including immune responses, cell signaling and energy metabolism to name a few, are conducted by the gut microbiota and its metabolites. LÄS MER

  4. 3. Implementation of a straightforward derivatizationmethod for the simultaneous analysis of short chainfatty acids and tricarboxylic acid cycle metabolitesby LC-qToF-MS.

    Kandidat-uppsats, Örebro universitet/Institutionen för naturvetenskap och teknik

    Författare :Renée Levisson; [2021]
    Nyckelord :Short-chain fatty acids; tricarboxylic acid TCA cycle; chemical derivatization; 3-nitrophenylhydrazine;

    Sammanfattning : Short-chain fatty acids (SCFAs) and the tricarboxylic acid (TCA) cycle metabolites aresmall hydrophilic compounds that play crucial roles in biological species ranging fromenergy metabolism, immune homeostasis to cellular signalling. There is a need for reliableand precise quantification of these metabolites in biological matrices as they can providecrucial information of metabolic status and potentially be used as diagnostic biomarkersfor different pathological and physiological conditions. LÄS MER

  5. 4. Quantifying metabolic fluxes using mathematical modeling

    Master-uppsats, Linköpings universitet/Institutionen för medicinsk teknik

    Författare :Victor Viberg; [2018]
    Nyckelord :Metabolic Flux Analysis; OpenFlux; carbon thirteen; Uncertainty Analysis; Cytoscape; Cancer; TCA-cycle; flux rate; metabolic reactions; systems biology; mathematical modeling; krebs cycle; model validation;

    Sammanfattning : Background Cancer is one of the leading causes of death in Sweden. In order to develop better treatments against cancer we need to better understand it. One area of special interest is cancer metabolism and the metabolic fluxes. As these fluxes cannot be directly measured, modeling is required to determine them. LÄS MER