Computational Simulations of Evolutionary Dynamics: The Fate of Deleterious Alleles
Sammanfattning: When a severe deleterious mutation appears in a population, it is expected to disappear through negative selection within a few generations. However, the variance of this number is significantly large to allow some deleterious mutations to exist for several generations. To extend the understanding about these dynamics can help to prevent and treat genetic disease in humans and other species. In order to understand this evolutionary process, computer simulations of deleterious mutations in populations have been performed. This will answer fundamental questions such as expected number of individuals affected by mutation, as well as number of generations until extinction. The approach of simulation will confirm results primarily calculated before, but will also outline completely new findings, such as how the average number of individuals in a mass of family lines with a deleterious mutation strives towards an equilibrium-like state, and how haplotype frequencies in a population can be used to find probable relationships between individuals with similar phenotype.
HÄR KAN DU HÄMTA UPPSATSEN I FULLTEXT. (följ länken till nästa sida)