The impact of cognitive reserve on the relationship between clinical expression and brain pathology in Alzheimer’s disease

Sammanfattning: There is two different ways to react to a disease like Mild cognitive impairment and Alzheimer’s disease, pathological and clinical. What if there was a way to delay the clinical expression of a disease through pathology? The cognitive reserve has been proven to show a more rapid decline in the individuals that had higher reserve. The purpose of this study was to see if the cognitive reserve actually had an impact on the outcome of Dementia and Alzheimer’s disease. A total of 53 patients with varying degrees of disease pathology and clinical symptoms participated in the study. The results demonstrated that the cognitive reserve makes an impact on the clinical expression, the individuals with high cognitive reserve have a delayed clinical expression comparatively with those with low reserve. Studies of the cognitive reserve may point the way to successful interventions that can help maintain successful aging and slow the onset of dementia.