Framtidens biomarkörer : En prioritering av proteinerna i det humana plasmaproteomet

Detta är en Kandidat-uppsats från Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för biologisk grundutbildning; Uppsala universitet/Institutionen för biologisk grundutbildn

Sammanfattning: In this report, we rank possible protein biomarkers based on different criteria for use in Olink Proteomics’ protein panels. We started off with a list compiled through the Human Plasma Proteome Project (HPPP) and have in different ways used this to obtain the final results. To complete this task we compared the list with Olink’s and its competitors’ protein catalogs, identified diseases beyond Olink’s coverage and the proteins linked with these. We also created a scoring system used to fa- cilitate detection of good biomarkers. From this, we have concluded that Olink should focus on proteins that the competitors have in their catalogs and proteins that can be found in many pathways and are linked with many diseases. From each of the methods used, we have been able to identify a number of proteins that we recommend Olink to investigate further.

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