Kan tillskott av probiotika ha effekt på stress och ångest?

Detta är en Kandidat-uppsats från Göteborgs universitet/Institutionen för medicin

Sammanfattning: AbstractTitle: Can supplementation of probiotics have an effect on stress and anxiety? -A systematic reviewAuthor: Emma Olsson & Susanna VallinSupervisor: Jenny van OdijkExaminer: Heléne Bertéus ForslundProgramme: Programme in dietetics, 180/240 ECTSType of paper: Bachelor’s thesis in clinical nutrition, 15 higher education credits Date: 21-03-31Background: Stress and anxiety as general symptoms affect many people. If these are experienced frequently and for a long time, it can lead to illness. There is a lot of ongoing research about how the intestinal flora can affect stress and anxiety through the "gut-brain axis". Probiotics provide several health benefits and can potentially also affect these symptoms.Objectives: The purpose of this systematic review was to investigate whether supplementation of single strain probiotic had an effect on stress and anxiety in stressed, adult individuals.Search strategy: A systematic literature search was performed in the databases PubMed and Scopus. Relevant keywords were used, for example ”Lactobacill'”, ”Bifidobacter'”, ”Probiotic'”, “Psychological Stress'”, “Perceived stress”, “Chronic Stress”, “Stress Symptoms”, ”Anxiety”, “Symptoms of Anxiety”, Random'” and ”blind'”.Selection criteria: Included: Healthy adults, 18-65 years, RCT studies written in Swedish or English, human studies, probiotic supplements as intervention and placebo as control, studies that have examined change in subjective stress or anxiety based on validated self-assessment scales and possible change in stress measured Like cortisol, the population consisted of stressed individuals determined from a questionnaire.Excluded: Studies that examined several probiotic strains without separating them, studies that had anintervention other than probiotic supplements alone or that did not report individual effects forprobiotics, studies where the intervention was "inactive" probiotics, studies where participants had a psychiatric diagnosis, secondary analyzes of RCT studies, pilot studies, studies published before the year 2000.Data collection and analysis: The search was conducted on 21-01-29 and generated a total of 398 hits. After reading the title and abstract, 18 articles remained to be read in full text. Four articles were selected forreview. After the results were analyzed, another article was excluded. Finally, three articles remained which were included in the review article. A quality review was first carried out with SBU's template “Assessment of randomized trials (effect of awarding an intervention (ITT))” and then the evidence was assessed with thetemplate “Basis for weighted assessment according to GRADE”.Main results: Two studies from Asia and one study from Europe were included. The study populationconsisted of 376 individuals. The interventions lasted between five and twelve weeks. The probioticsstudied consisted of different strains of lactobacilli of similar concentration. The effect was measured withself-assessment scales (PSS-10 and DASS) and cortisol tests. The results for PSS-10 were not consistent between the studies, only one of the studies showed significantly reduced stress levels in the interventiongroup compared to control. No significant results were seen for stress and anxiety measured with DASS.Only one of the studies could show a significant reduction in cortisol levels. However, this value wasdifficult to compare with the other two studies.Conclusions: There is a low reliability (++) that supplementation with probiotics may not have an effect on perceived stress and anxiety and very low reliability (+), in other words, it is not possible to assess whether supplementation with probiotics dose not have an effect on the stress marker cortisol.

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