Har supplementering av vitamin D effekt på depression hos vuxna? En systematisk litteraturöversikt av randomiserade, placebo-kontrollerade studier
Sammanfattning: AbstractTitle: Does the supplementation of vitamin D in adults have an effect on depression?- A systematic review of randomized, placebo-controlled trialsAuthor: Linda Andersson, Gabrielle Winther, Therese AlmSupervisor: Linnea BärebringExaminer: Anna WinkvistProgramme: Programme in dietetics, 180/240 ECTSType of paper: Bachelor´s thesis in clinical nutrition, 15 higher education creditsDate: 2021-03-31Background: Depression is one of our greatest endemic diseases and affects people of all ages. With more than 264 million people affected in the world, depression is one of the most common causes of illness, loss of productivity, and incapacity for work. Research has shown a correlation between depression and low levels of vitamin D, as well as the fact that the vitamin and its concurrent factors are found in parts of the brain controlling emotions and behavior. Objective: The objective of this review was to examine if there is any scientific basis for supplementation of vitamin D having an effect on depressive symptoms in adults.Search strategy: The literature search was conducted in databases PubMed and Scopus. The keywords were split into four parts, one concerning vitamin D, one for depression, one for dietary supplementation, as well as one for including randomized trials.Selection criteria: Included studies were RCTs using vitamin D supplements on depressed adults, ages 18-75. The trials had to be at least four weeks long and written in the Swedish or English languages. Non-blinded trials, trials using multivitamins, as well as trials conducted on individuals with chronic diseases other than depression, were excluded.Data collection and analysis: Articles were screened for their relevance and three were chosen. These were further reviewed according to a template used for determining the risk of a study being biased, and the overall quality of the studies was determined using the GRADE template.Main results: Three studies were reviewed – two of which were rated as having medium study quality and one as having high study quality. Two studies showed vitamin D having no effect on depression whilst the third one indicated a possible effect.Conclusions: Supplementation of vitamin D in doses ranging from 70 to 125 µg/day to 1250 µg/week for 8-12 weeks, does not seem to improve depressive symptoms amongst adults with clinical depression (++).
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