The effect of addition of a dry binder on compaction properties of dry granulated particles

Detta är en Master-uppsats från Uppsala universitet/Institutionen för farmaceutisk biovetenskap

Författare: Rashin Esnaashari Esfahani; [2021]

Nyckelord: PVP; tensile strength;

Sammanfattning: The purpose of this study was to examine the influence of content of a copovidone binder (0%, 5% and 10% w/w) and its addition method on compression and compaction properties of six MCCformulations following dry granulation. Briquetting was used to form dry granules for furthercharacterization. The mean yield pressure and fracture strength of granules were assessed at 300MPa on the basis of “in-die” Heckel and Adams model respectively. Then tablet tensile strengthof manufactured tablets was determined at 100 and 300 MPa. The results demonstrated thatintragranular addition of further binder (10%) to MCC could increase plasticity. However, therewas a drastic reduction in compactibility of dry granules mostly impacted by binding capacity ofthe binder. Generally, 5% intragranular:5% extragranular binder under a compaction pressure of300 MPa had the greatest binder efficacy on strength of pure MCC tablets while 10%extragranular binder improved tensile strength significantly at 100 MPa. PVP in a level of 5%w/w had no significant impact on tensile strength of tablets compacted at 100 and 300 MPa.

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