Kan ett ökat intag av omega-3 fettsyror ha en påverkan på testosteron, insulin och insulinkänslighet hos kvinnor med PCOS?

Detta är en Kandidat-uppsats från Göteborgs universitet/Institutionen för medicin

Sammanfattning: Sahlgrenska Academyat University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: Can a higher intake of omega-3 fatty acids have an impact ontestosterone, insulin and insulin resistance in women with PCOS?Author: Alicia Hedlund and Victoria WestrinSupervisor: Frode SlindeExaminer: Anna WinkvistProgramme: Programme in dietetics, 180/240 ECTSType of paper: Bachelor’s thesis in clinical nutrition, 15 hpDate: 8th of April 2015Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrinedisorder among fertile women and circa 234 000 Swedish women suffer from the syndrome.High levels of androgens, oligoamenorrhea or amenorrhea and anovulation are commoncharacteristics of PCOS. A common problem is infertility. Today there are no guidelines forany specific nutrition therapy that could reduce infertility among women with the syndrome.Objective: To evaluate the scientific evidence available in order to investigate whetheromega-3 fatty acids have an impact on the levels of free testosterone, total-testosterone,insulin and insulin resistance in women with PCOS.Search strategy: The databases PubMed, Scopus and Cochrane Library were used in theliterary search. Keywords were used and combined in different ways: omega-3, pcos,polycystic ovary syndrome, gonadal hormones, polyunsaturated dietary fats, eicosapentanoicacids, fatty acids, gonadal steroid hormones, DHA, EPA, ALA. MeSH-terms were also used.Selection criteria: Human studies of RCT or Clinical Trial, written in Swedish or English,were selected as inclusion criterias. Participants were females with PCOS in reproductive age,diagnosed with the Rotterdam criteria or NIH criteria. Studies with omega-3 supplementationas capsules or oil were included. Studies using food as supplement or including otherandrogen hormones except testosterone, androstenedione and DHEAS were excluded.Data collection and analysis: Two RCT and one intervention study were selected for review.The template “Mall för kvalitetsgranskning av randomiserade studier” from SBU was used toevaluate the quality of the papers. The template “Underlag för sammanvägd bedömning enligtGRADE” from SBU was used to evaluate the total evidence for every outcome measures.Main results: Altogether the results from this literature review show a reduction in the levelsof free testosterone, total-testosterone, insulin and reduced insulin resistance. Two of twostudies showed significant effect in free testosterone while one of two studies showedsignificant effect in total-testosterone. Two of three studies reported significant effect ininsulin levels and insulin resistance.Conclusions: There is moderate (+++) evidence for recommending omega-3 as nutritiontherapy in order to reduce levels of free testosterone, insulin and to reduce insulin resistance.There is limited (++) evidence that omega-3 can reduce levels of total-testosterone.

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