Kan tillskott av essentiella aminosyror utan samtidig träning öka muskelmassa hos friska äldre och äldre med sarkopeni? - En systematisk översiktsartikel

Detta är en Kandidat-uppsats från Göteborgs universitet/Institutionen för medicin

Sammanfattning: Title: Can supplements of essential amino acids increase muscle mass inhealthy elderly and elderly with sarcopenia?- A systematic reviewAuthor: Axelie Petersson and Donny KarlssonSupervisor: Frode SlindeExaminer: Anna WinkvistProgram: Programme in dietetics, 180/240 ECTSType of paper: Bachelor’s thesis in clinical nutrition, 15 higher education creditsDate: March 27, 2018Background: Older people (> 65 years) form a large part of the population and are the largestpatient group in health care. Reduced muscle mass and muscle function are a natural part ofaging, and in elderly patients the process of muscle synthesis is impaired. Loss of muscle masscan cause increased fragility and reduced quality of life in the elderly. High intake of protein inthe form of essential amino acids (EAA) with content of the branched amino acid Leucine hasbeen shown to have a positive effect on muscle synthesis in healthy adults and elderly atconcomitant weight training compared to placebo. However, few studies and surveys haveinvestigated whether supplements of EAA to elderly have an effect on muscle mass withoutsimultaneous exercise.Objective: The purpose of this systematic review article was to investigate the scientific basisfor supplementation with essential amino acids without simultaneous exercise in healthyelderly and elderly with sarcoma has a single effect on muscle mass.Search strategy: The databases PubMed and Scopus were used to find scientific originalarticles. Block containing keywords and synonyms were used and merge to capture all articlesthat could affect our issue.Selection criteria: Studies that investigated the potential effect of essential amino acids asincreased muscle mass in elderly people.Data collection and analysis: Four articles were selected according to the inclusion criteriaand quality-reviewed using SBU's "RCT review template". Evidence strength for selectedendpoint of muscle mass was then graded from the University of Gothenburg template"Underlag för sammanvägd bedömning enligt GRADE".Main results: Significant increases in muscle mass were seen in the EAA groups frombaseline in both studies for healthy elderly. However, mixed results were shown in the twostudies for elderly patients with sarcopenia where one study showed significant difference frombaseline after EAA supplementation and the second study showed no significant increase inmuscle mass in the EAA group, either from baseline or compared to control group.Conclusions: Evidence strength for supplementation of amino acids without simultaneousexercise increases muscle mass in healthy elderly patients was low (++) and evidence ofelderly with sarcopenia very low (+).Keywords: essential amino acids, muscle mass, elderly, sarcopenia, frailty

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