Sökning: "cytotoxic payload"

Hittade 2 uppsatser innehållade orden cytotoxic payload.

1. 1. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

   Författare :Astrid Haraldsson; [2023]
   Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

   Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

3. 2. Antibody drug conjugates (ADC) : Current status and mapping of ADC:s in clinical programs

   Kandidat-uppsats, Uppsala universitet/Institutionen för teknikvetenskaper

   Författare :Samantha Congreve; Reham Faris Elias; Gabriel Tidestav; Venus Zafranian; [2018]
   Nyckelord :ADC; antibody; drug; conjugate; biopharmaceuticals; structure; linker; payload; target; conjugation; market;

   Sammanfattning : A literature study was performed on a new type of cancer medicine: antibody drug conjugates, or ADCs. These consist of a monoclonal antibody, chemically linked to a cytotoxic agent. What makes them unique is their selective toxicity against cancer cells. LÄS MER