Sökning: "marker discovery"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden marker discovery.

  1. 1. Molecular mapping of the HGSOC tumour microenvironment

    Master-uppsats, Uppsala universitet/Institutionen för medicinsk biokemi och mikrobiologi

    Författare :Philippine Louail; [2023]
    Nyckelord :Immunology; Ovarian cancer; Multiplex Immunofluorescence; scRNA sequencing; Bioinformatics; Image analysis;

    Sammanfattning : High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, and its heterogeneity poses a challenge for the discovery of reliable diagnostic biomarkers, therapeutic targets, and predicting treatment response, particularly to immunotherapy. The current standard diagnostic and treatment options are inadequate, resulting in late diagnosis and poor prognosis. LÄS MER

  3. 2. Identifying molecular markers for breeding a future oil crop, Lepidium campestre

    Master-uppsats, SLU/Dept. of Plant Breeding (from 130101)

    Författare :Noomi Lodenius; [2023]
    Nyckelord :glucosinolate content; interspecific hybridization; Lepidium campestre; marker discovery; oil content; oil quality;

    Sammanfattning : The cold hardy novel oil- and cover crop Lepidium campestre is currently being domesticated as a potential oil crop for the Nordic region. To achieve this objective, multiple traits have previously been identified as desirable to improve, including seed oil content and composition, and glucosinolate (GL) content. LÄS MER

  4. 3. Cancer Driver Gene Detection using Deep Convolutional Neural Networks on H3K4me3 Enrichment Profiles

    Master-uppsats, Lunds universitet/Institutionen för astronomi och teoretisk fysik - Genomgår omorganisation

    Författare :Marc Pielies Avellí; [2022]
    Nyckelord :Cancer Driver CD Gene; Histone Post-Translational Modifications PTMs ; Convolutional Neural Networks CNNs .; Physics and Astronomy;

    Sammanfattning : In spite of our current knowledge regarding the biology underlying cancer genesis, reliable methods for the discovery of cancer driver (CD) genes are still in great need. The rather recent incorporation of epigenetic markers to the cancer paradigm has nevertheless opened the door for the development of new computational approaches to the problem. LÄS MER

  5. 4. Sepsis and circulating miRNA : The road towards absolute quantification of unknown miRNA levels in plasma utilizing two-tailed RT-qPCR, while testing two extraction methods, striving to create multi-marker panel for sepsis diagnosis

    Magister-uppsats, Högskolan i Skövde/Institutionen för biovetenskap

    Författare :Hazzim Elawad; [2021]
    Nyckelord :;

    Sammanfattning : Sepsis is a preventable yet life threatening condition, resulting from body response to infection. Time is crucial in sepsis diagnosis since deterioration in patients’ health can occur rapidly. Blood culturing is the gold standard for diagnosis, along with clinical assessment. LÄS MER

  7. 5. Effects of Different Laminins on Human Neural Progenitor Cells Cultured in 3D Electrospun Fibers

    Master-uppsats, Lunds universitet/Tillämpad biokemi; Lunds universitet/Beräkningskemi

    Författare :Karl Vesterlund; [2019]
    Nyckelord :two-dimensional; three-dimensional; Alamar Blue; cell culture; drug development; extra-cellular matrix; electrospinning; immunocytochemistry; laminin; polycaprolactone; polymerase chain reaction; western blot; applied biochemistry; tillämpad biokemi; Technology and Engineering; Biology and Life Sciences;

    Sammanfattning : A low success rate of drug candidates in clinical trials, and especially in brain research, motivates development of better screening models. Hence, in neuroscience and many other fields of Life Science, development of more physiological relevant experimental cell-based models is motivated. LÄS MER