Sökning: "NONMEM"

Visar resultat 1 - 5 av 10 uppsatser innehållade ordet NONMEM.

  1. 1. Translation of pharmacometric models from NONMEM to nlmixr2 and RxODE2

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Johan Borg; [2023]
    Nyckelord :pharmacy; pharmacokinetics; pharmacodynamics; nlmixr; nlmixr2; rxode; rxode2; conversion; translation; NONMEM; PK; PD; PK PD; model; modeling; modelling;

    Sammanfattning : The gold standard for pharmacometrics modeling, along with its modeling format, is currently NONMEM. In order to use other software, there is often a manual step of converting a model from one format to another, which is both time-consuming and causes manual errors. LÄS MER

  3. 2. Automatic Development of Pharmacokinetic Structural Models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Alzahra Hamdan; [2022]
    Nyckelord :pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Sammanfattning : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. LÄS MER

  4. 3. Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Karin Norgren; [2021]
    Nyckelord :Population PK modeling; Pharmacometrics; NLME modeling;

    Sammanfattning : Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. LÄS MER

  5. 4. Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Albin Leding; [2021]
    Nyckelord :Pharmacokinetics; Pharmacometrics; Pharmacology; population pharmacokinetics; physiologically-based pharmacokinetics; in vitro to in vivo extrapolation; IVIVE; PBPK; PK; popPK; tuberculosis; model informed approach; first in vivo pharmacokinetic experiment; mouse; mice; PKSim; NONMEM; in vitro; in vivo;

    Sammanfattning : Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. LÄS MER

  7. 5. Implementation of an automatic quality control of derived data files for NONMEM

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Eric Sandström; [2019]
    Nyckelord :;

    Sammanfattning : A pharmacometric analysis must be based on correct data to be valid. Source clinical data is rarely ready to be modelled as is, but rather needs to be reprogrammed to fit the format required by the pharmacometric modelling software. LÄS MER