Sökning: "Pharmacology"

Visar resultat 1 - 5 av 28 uppsatser innehållade ordet Pharmacology.

  1. 1. Quantification of Pharmaceuticals at the sub-cellular level using the NanoSIMS

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Analytisk kemi

    Författare :Maryam Dost; [2024]
    Nyckelord :Mass spectroscopy imaging; AstraZeneca; Nanosims; Therapeutics; pharmacokinetics; pharmacodynamics; Quantitative Visualization; calibration curve; RSF; pharmacology; Data Analysis; Chemistry; Quantification; isotopes; Pharmaceuticals; subcellular; drug; drug target; nucleotide; biodistribution; Bioanalytical electrochemistry; spectroscopy; mass spectrometry; analytical separations; Analytical Chemistry; ROI; Bioanalytical Chemistry; Masspektroskopi avbildning; AstraZeneca; Nanosims; Terapeutik; farmakokinetik; farmakodynamik; Kvantitativ visualisering; kalibreringskurva; RSF; farmakologi; Dataanalys; Kemi; Kvantifiering; isotoper; Läkemedel; subcellulär; läkemedel; läkemedelsmål; bioskopisk elektrofördelning; nukleotid; bioskopisk bioskopisk distribution; masspektrometri; analytiska separationer; analytisk kemi; bioanalytisk kemi;

    Sammanfattning : Mass spectroscopy imaging (MSI) has become a vital tool in modern research due to its ability to visualize the spatial distribution of molecules within tissue samples. The collaboration between researchers at AZ, the University of Gothenburg, and Chalmers University of Technology using the NanoSIMS instrument and MSI-SIMS technology has opened up new avenues of exploration in pharmaceutical development, particularly in examining drugs and metabolites at sub-cellular levels. LÄS MER

  3. 2. Sjuksköterskors upplevelser av att vårda barn och ungdomar med smärta inom postoperativ vård : En systematisk litteraturöversikt

    Magister-uppsats, Högskolan i Borås/Akademin för vård, arbetsliv och välfärd

    Författare :Adam Vestin; Erik Storm; [2023]
    Nyckelord :Postoperative pain; nurse; experience; child; adolescent; Postoperativ smärta; sjuksköterskor; upplevelse; barn; ungdomar;

    Sammanfattning : Barn och ungdomar har rätt till en god hälso- och sjukvård som bygger på evidens. I rollen som anestesisjuksköterska innefattas det flera utmanande beslut för att behandla postoperativ smärta. Vården är komplext då det är flera aspekter som behöver tas i beaktning. LÄS MER

  4. 3. Automated Quantitative Phase Imaging Pipeline : for Monitoring Bacterial Cell Growth under Chemical Influence

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Avdelningen Vi3

    Författare :Samuel Zargani; [2023]
    Nyckelord :image analysis; QPI; Quantitative Phase Imaging; QLSI; kvantitativ fasavbildning; Bildanalys;

    Sammanfattning : Bacteria have a vital role in ecosystems and the human health. However, the effect of environmental pollution on them at the single-cell level are still not well understood. Label-free imaging has become increasingly important within science. It has allowed for the visualization of cells without the use of molecular tools or labels. LÄS MER

  5. 4. An Interactive MIDD Framework for Evaluation and Comparison of PBPK Model Performance

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Dylan Garamani; [2022]
    Nyckelord :MIDD; PBPK; QSP; PK; GUI;

    Sammanfattning : Modeling and simulation are becoming indispensable elements in drug development. Mechanistic modeling is susceptible to impacting several drug development and regulatory decisions through extrapolations beyond clinically researched scenarios by using its capacity to incorporate diverse data to provide a detailed and comprehensive understanding of a physiological and biological system. LÄS MER

  7. 5. Pharmacokinetics: A comparison of physiologically based pharmacokinetic models : A comparison study

    Kandidat-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Rosa Kafey; [2022]
    Nyckelord :PBPK; MODELLS;

    Sammanfattning : Abstract Background: This thesis explores the pharmaceutical model physiologically based pharmacokinetics (PBPK) further and focuses on the basics of parameters used for the software tools to develop new drugs on the market today. Further reflects on what drug companies place their importance on when developing a new drug and why, by focusing on 29 different drugs and the parameters provided by the PBPK-model. LÄS MER