Sökning: "non-linear mixed effects"

Visar resultat 1 - 5 av 7 uppsatser innehållade orden non-linear mixed effects.

  1. 1. Population Pharmacokinetics of Linezolid for Optimization of the Treatment for Multidrug Resistant Tuberculosis

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Viktor Hansen; [2022]
    Nyckelord :tuberculosis; drug resistance; pharmacometrics; pharmacokinetics; pop-pk; south africa; non linear mixed effects modelling; nlme;

    Sammanfattning : Tuberculosis is one the leading causes of death globally and was before the COVID-19 pandemic the leading cause of death from a single infectious agent. Developing active tuberculosis is life threatening and therefore is the rise of drug-resistant tuberculosis alarming as this risk causing current treatments to become ineffective. LÄS MER

  3. 2. Applicability of Graph Neural Networks to predict Human variability in Human Body Model Rib Strain Predictions

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Statistik, AI och data science

    Författare :Julia Solhed; [2022]
    Nyckelord :Graph Neural Networks; Human Body Model; SAFER HBM; HBM simulation; Rib strain predictions; Rib fracture risk predictions;

    Sammanfattning : Finite element human body models have in recent years become widely used in the area of vehicle safety evaluations. They make it possible to predict injury risk in specific areas, down to the organ level in the human body. An existing human body model, SAFER HBM includes a rib cage representing an average male. LÄS MER

  4. 3. Automatic Development of Pharmacokinetic Structural Models

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Alzahra Hamdan; [2022]
    Nyckelord :pharmacometrics; non-linear mixed effects; modelling; pharmacokinetics; NONMEM; automation; exhaustive algorithm; stepwise algorithm; structural models; inter-individual variability; residual error models; model selection;

    Sammanfattning : Introduction: The current development strategy of population pharmacokinetic models is a complex and iterative process that is manually performed by modellers. Such a strategy is time-demanding, subjective, and dependent on the modellers’ experience. LÄS MER

  5. 4. Evaluation of Robust Model Building Tools to Improve the Efficiency of Non-linear Mixed Effect Model Building Workflows

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

    Författare :Karin Norgren; [2021]
    Nyckelord :Population PK modeling; Pharmacometrics; NLME modeling;

    Sammanfattning : Population PK models aim to describe the change in drug concentration over time for a specific population. The populations in population PK modelling often refer to subjects in a clinical trial of a potential drug candidate. LÄS MER

  7. 5. Predictability and performance of different non-linear mixed-effects models for HbA1c in patients with type 2 diabetes mellitus

    Master-uppsats, Institutionen för farmaceutisk biovetenskap; Institutionen för biologisk grundutbildning

    Författare :Gustaf Wellhagen; [2014]
    Nyckelord :Type 2 diabetes mellitus; semi-mechanistic models; HbA1c; glucose; insulin; NONMEM;

    Sammanfattning : To accurately predict the outcome of a late phase study, pharmacometric models can help in drug development. Making informed decision on which models to use will also facilitate drug development. This can depend on the mechanism of action for the drug as well as stability and runtime factors. LÄS MER