Sökning: "neurotransmitter receptor"

Visar resultat 1 - 5 av 8 uppsatser innehållade orden neurotransmitter receptor.

  1. 1. CGRP-hämmare i form av monoklonala antikroppar som profylax mot episodisk och kronisk migrän

    Kandidat-uppsats, Linnéuniversitetet/Institutionen för kemi och biomedicin (KOB)

    Författare :Jenny Gröhn; [2020]
    Nyckelord :CGRP; CGRP-receptor; episodisk migrän; eptinezumab; erenumab; fremanezumab; galcanezumab; kalcitoningenrelaterad peptid; kronisk migrän; monoklonala antikroppar;

    Sammanfattning : Background: Migraine is a common disease with a global prevalence of about 15%. Migraine is divided into two main types; migraine with aura or migraine without aura. Migraine symptoms include moderate or severe unilateral pulsating pain exacerbated by physical activity, nausea and vomiting as well as light and sound sensitivity. LÄS MER

  3. 2. The effect of caffeine on anxiety-like behavior in rats

    Master-uppsats, Uppsala universitet/Institutionen för farmaceutisk biovetenskap

    Författare :Evelina Meurling; [2020]
    Nyckelord :;

    Sammanfattning : Adenosine is a neurotransmitter suggested to be involved in the mediation of anxiety in the brain by acting on adenosine receptors. High doses of caffeine, which is an adenosine receptor antagonist, can induce anxiety – like effects in both animals and humans, but the precise mechanism of action is still debated. LÄS MER

  4. 3. Computational Modeling and Characterization of the Human Tri-Heteromeric GABAA Receptor

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Michael Luxemburg; [2019]
    Nyckelord :;

    Sammanfattning : -aminobutyric acid receptors of type A (GABAARs) are the majorinhibitory neurotransmitter receptors in the human brain, andare modulated by a vast range of exogenous molecules, such assedatives and anesthetics. In the last year, the first cryo-electronmicroscopy (cryo-EM) images of the closed and desensitized statesof the GABAAR were released, enabling fruitful research throughsimulations of these complex proteins. LÄS MER

  5. 4. Characterization of the binding of the novel compound GT-002 to GABAA receptors in the mammalian brain : Development and validation of a radioligand binding assay. A comparative study to Flumazenil

    Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologi

    Författare :Zemowska Emelie; [2017]
    Nyckelord :GABAA receptor; Radioligand binding assay; GT-002; Triazoloquinazolinedione; Flumazenil; Neuropharmacology;

    Sammanfattning : Gamma-Amino butyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and inhibits the neurotransmission by targeting the ionotropic transmembrane GABAA receptor. Modulators of the GABAA receptor targets the allosteric binding sites and modifies the GABA effect and these sites acts as superior drug targets within psychopharmacology. LÄS MER

  7. 5. Domestication related genotype on ADRA2C - a determinant of fear response in chickens?

    Master-uppsats, Institutionen för fysik, kemi och biologi; Tekniska högskolan

    Författare :Amir Fallahshahroudi; [2012]
    Nyckelord :Chicken; Fearfulness; Genetics; Domestication; ADRA2C;

    Sammanfattning : White Leghorn (WL) breed is homozygous for an allele on the α2C-AR gene while the Red Junglefowl (RJF) is mostly heterozygous for that. The gene is also hypermethylated in WL. LÄS MER