Sökning: "Chromatography"

Visar resultat 16 - 20 av 476 uppsatser innehållade ordet Chromatography.

1. 16. A novel approach for functionalising and separating Tröger's Base Analogues

   Master-uppsats, Lunds universitet/Centrum för analys och syntes

   Författare :Emil Jakobsson; [2023]
   Nyckelord :Tröger s Base; Synthesis; Chromatography; Supramolecular chemistry; Diastereomers; Organic chemistry; Chemistry;

   Sammanfattning : Tröger’s Base (TB) is a bicyclic compound containing a methanodiazocine group between two aromatic rings. The methylene bridge forces the molecule to have a bent formation; thus, the aromatic rings are close to 90 degrees relative to each other, resulting in a rigid concave aromatic cavity. LÄS MER

3. 17. Design, production and in vitro evaluation of brain shuttle scFc-scFv8D3 affinity-mutants

   Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Institutionen för farmaci

   Författare :Jonathan Efverström; [2023]
   Nyckelord :Blood-brain barrier; In-Cell BBB-trans assay; mTfR1; Transferrin receptor; scFc-scFv8D3; Blod-hjärn barriären; mTfR1; Transferrin receptorn; scFc-scFv8D3;

   Sammanfattning : The blood brain barrier (BBB) is a challenge when developing monoclonal antibodies for neurological diseases as antibodies do not cross the BBB making brain distribution challenging. An antibody construct which binds mTfR1 to pass the BBB, scFc-scFv8D3, have previously been developed. LÄS MER

4. 18. Navigating Large-Scale Plasmid DNA Purification : A Recommendation of Current and Future Downstream Purification Solutions

   Kandidat-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

   Författare :Matilda Eriksson; Alva Wells; Maria Frey; Lisa Johansson; Gabriel Pettersson; David Sjöberg; [2023]
   Nyckelord :Plasmid purification; pDNA; large-scale chromatography;

   Sammanfattning : Previous small-scale methods for plasmid DNA (pDNA) purification fail to meet theindustry’s demand for sufficient quantities. Greater volumes of bacterial lysates are a consequence of larger volumetric fermentations and traditional large-scale down-stream purification processes have some disadvantages and limitations. LÄS MER

5. 19. Geobacillus 7349 – A new potential biosurfactant producing microorganism

   Master-uppsats, Lunds universitet/Bioteknik (master); Lunds universitet/Bioteknik (CI)

   Författare :Zhuoying Deng; [2023]
   Nyckelord :biosurfactant; rhamnolipids; HPLC; HPAEC-PAD; bacteria growth; downstream purification; liquid-liquid extraction; biotechnology; Chemistry;

   Sammanfattning : The main aim of this master project is to find out whether strain Geobacillus 7349 can produce biosurfactant during their growth by extraction and characterization of the product. The other goal is to optimize the cultivation condition of the strain. LÄS MER

7. 20. Methods to study device induced aggregation of proteins

   Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

   Författare :Marie Therese von Wowern; [2023]
   Nyckelord :protein formulation; protein aggregation; insulin; silicone oil; syringe; shear stress; subvisible particle; size exclusion chromatography; flow imaging microscopy; pharmaceutical technology; Technology and Engineering;

   Sammanfattning : This work developed a method for the investigation of how medical devices, such as syringes and needles, affect the formation of subvisible particles in a protein drug without excipients. Protein-based pharmaceuticals are well known to be sensitive to different kinds of stress, and exposure to stress during the use of this device is unavoidable. LÄS MER