Sökning: "peptide"

Visar resultat 1 - 5 av 184 uppsatser innehållade ordet peptide.

  1. 1. Expression optimization in Pichia pastoris with Signal Peptide Shuffling and characterization of putative oxygenases and glucose oxidase

    Master-uppsats, Uppsala universitet/Institutionen för biologisk grundutbildning

    Författare :Anna Wolters; [2024]
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  3. 2. Creating a High-Throughput Workflow for Automated Peptide Characterization using LC-MS

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Sara Forsberg; [2023]
    Nyckelord :High-throughput analysis; Impurity profiling; UHPLC-HRMS; Peptide characterization; Peptide descriptors; Analytical chemistry; Technology and Engineering;

    Sammanfattning : In the early stage of a drug discovery project, there is a need for efficient methods that can analyse peptides in short time. This includes methods that confirm the peptide’s identity and estimates its relative purity in an efficient and reliable way. LÄS MER

  4. 3. Development of a PNA-drug conjugate for pretargeted delivery of cytotoxic drugs

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Theranostics

    Författare :Astrid Haraldsson; [2023]
    Nyckelord :PNA; pretargeting; cancer therapy; cytotoxic payload;

    Sammanfattning : One of the major challenges in cancer treatment is delivering high enough doses of active substance specifically to cancer cells without accumulation in healthy organs. Pretargeting has emerged as a potential solution, where the delivery of a cancer recognizing (primary) agent and a cancer killing (secondary) agent are separated. LÄS MER

  5. 4. Understanding the effects of TCP-25 and EDTA interaction : A study of the biophysical aspects of a naturally derived peptide formulation with EDTA for topical application

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Ebba Kant; [2023]
    Nyckelord :chronic wounds; EDTA; biophysical aspects; formulation; pharmaceutical technology; Thrombin derived C-terminal peptide; Technology and Engineering;

    Sammanfattning : Chronic wounds are an emerging healthcare issue and current methods of healing chronic wounds address bacteria but are ineffective against resistant bacteria and the biofilm formation commonly observed in these wounds. Antimicrobial peptides (AMPs) derived from the endogenous wound healing system have been shown to combat bacterial infections, exhibit immunomodulatory effects, as well as improving wound healing. LÄS MER

  7. 5. Design and Evaluation of Peptide Binders : In silico evaluation and comparison of generative AI for de novo peptide binder design

    Uppsats för yrkesexamina på avancerad nivå, Uppsala universitet/Beräkningsbiologi och bioinformatik

    Författare :Linde Brokmar; [2023]
    Nyckelord :Protein design; de novo design; protein engineering; generative ai; machine learning; peptide binders; AF2; EvoBind; RFdiffusion; ProteinMPNN;

    Sammanfattning : Peptide binders are short proteins that bind to larger proteins. Due to peptide binders having high specificity and being cheap to synthesize, they are a prime candidate for drug design. Creating new proteins in silico can be divided into three steps: protein backbone generation, sequence design, and computational filtering. LÄS MER