Sökning: "DOPC"

Hittade 5 uppsatser innehållade ordet DOPC.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Författare :Elina Edidovica; [2024]
    Nyckelord :Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER

  3. 2. Comparison and optimization of extracellular vesicle (EV) capturing on functional thin films for their molecular profiling

    Master-uppsats, KTH/Tillämpad fysik

    Författare :Prattakorn Metem; [2023]
    Nyckelord :extracellular vesicle; plasmonic nanohole array; atomic force microscopy; fluorescence analysis; extracellulära vesiklar; nanohålsuppsättning; atomkraftsmikroskopi; fluorescensanalys;

    Sammanfattning : Extracellular vesicles (EVs) are lipid bilayer encapsulated nanoparticles which have emerged as an excellent source of biomarkers for multiple diseases, including cancer. However, they are highly heterogeneous in their molecular compositions which remains a major challenge hindering the utilization of their biomarker potential. LÄS MER

  4. 3. Lipid bilayers and their interactions with the antimicrobial peptide LL37: a TIR Raman study

    Master-uppsats, KTH/Skolan för kemivetenskap (CHE)

    Författare :Rebecca Jacob; [2016]
    Nyckelord :TIR; Raman; LL37; lipid; bilayers; antimicrobial; peptide; AMP; resistance; antibiotics; DMPC; DOPC; DOPE; DOPG;

    Sammanfattning : As a direct consequence of the misuse of antibiotics since its first discovery, bacteria have developed extensive resistance mechanisms making them once again potential lethal threats. This eventuality has triggered a vast research effort from scientists worldwide to find solutions to mitigate antimicrobial resistance. LÄS MER

  5. 4. Characterization of enzyme sensitive responsive hydrogel/lipid system for triggered release

    Master-uppsats, Institutionen för farmaci

    Författare :Pétur Jónsson; [2013]
    Nyckelord :enzyme sensitive responsive hydrogel lipid system for triggered release; liposomes; mesoporous silica; ellipsometry; coating;

    Sammanfattning : This master thesis aimed to create and characterize multilayer coatings upon mesoporous silica particles (MSP). The properties of the coating aimed for, was to have a triggerable controlled release, where a targeted enzyme within the intestine, alpha-amylase, is supposed to degrade the coating. LÄS MER

  7. 5. Cardiolipin in phospholipid bilayers : a calorimetric study

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :My Mattsson; [2012]
    Nyckelord :Fysikalisk kemi; Chemistry;

    Sammanfattning : The purpose of this study was to understand cardiolipins behavior in different pH: 5.5, 7 and 9. Cardiolipins miscibility in other bilayers as 1,2-dimyrilstoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) were also studied. The instrument used in this study was a differential scanning calorimetry. LÄS MER