Sökning: "Cryo-TEM"

Visar resultat 1 - 5 av 8 uppsatser innehållade ordet Cryo-TEM.

  1. 1. Exploring alternative surfactants to replace PEG within lipid nanoparticles

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master); Lunds universitet/Bioteknik (CI); Lunds universitet/Bioteknik (master)

    Författare :Elina Edidovica; [2024]
    Nyckelord :Lipid nanoparticle; polyethelyne glycol PEG ; alpha-tomatine; N-hexadecyl beta d-maltoside HDM ; DOPC; DPPC; cholesterol; film hydration; stability study; DLS; Cryo-TEM; SAXS; pharmaceutical formulation; Chemistry;

    Sammanfattning : Over the past decade an increasing amount of studies has demonstrated that PEGylation not only precipitates reductions in drug delivery efficiency but also triggers the immune system to produce antibodies, specifically anti-PEG antibodies. The objective of my thesis is to explore alternative surfactants that could viably replace PEG within lipid nanoparticles. LÄS MER

  3. 2. Optimising microfluidic preparation of lipid sponge phase nanoparticles for biomolecule encapsulation

    Master-uppsats, Lunds universitet/Kemiteknik (CI)

    Författare :Owais Khalil; [2023]
    Nyckelord :Sponge phase; lipid nanoparticles; microfluidics; SAXS; cryo-TEM; DLS; chemical engineering; Chemistry;

    Sammanfattning : Drug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. LÄS MER

  4. 3. Självaggregering i blandningar av gallsalteroch fosfolipid undersöktes med statiskoch dynamisk ljusspridning vid 21 ̊ C och 37 ̊ C

    Master-uppsats, Uppsala universitet/Institutionen för farmaci

    Författare :Robabeh Kheirkhah Abkenar; [2021]
    Nyckelord :NaC; natrium cholat; NaDC; natriumdeocykolat; DMPG; anjonic lipid dimyristoyl fosfatidylglycerol;

    Sammanfattning : Introduction: Phospholipids amphiphilic structure gives them special properties such as self-aggregation, emulsifying and wetting properties. Among the various structures resulting from the dissolution of phospholipids in water are the liposome, which acts as a drug carrier. LÄS MER

  5. 4. Aqueous self-assembly behaviour alteration derived from primary structure changes of model peptides

    Master-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Marcus Bäcklund; [2020]
    Nyckelord :Model peptides; self-assembly; SAXS; FTIR; CD; physical chemistry; fysikalisk kemi; Chemistry;

    Sammanfattning : Understanding of the self-assembly behaviour of peptides is of great interest within several different areas such as neurodegenerative diseases, biotechnology, and peptide pharmaceuticals. In this work we have compared the impact on the self-assembly behaviour derived from systematic changes of the primary structure of A8K, where A denotes alanine and K lysine. LÄS MER

  7. 5. Lipid liquid crystalline phase and starch particle mixed formulations

    Kandidat-uppsats, Lunds universitet/Kemiska institutionen

    Författare :Cindy Phan; [2018]
    Nyckelord :physical chemistry; fysikalisk kemi; lipid liquid crystals; starch; cubic phase; Chemistry;

    Sammanfattning : Lipid liquid crystals (LLC) have been studied widely because of their broad application in both food- and pharmaceutical industry. Inverse bicontinuous cubic phase of LLC have been of particular interest as it has three-dimensional structure and has been proven to be able to incorporate and deliver substances (e.g. topical drug delivery). LÄS MER