Sökning: "aggregation"

Visar resultat 21 - 25 av 431 uppsatser innehållade ordet aggregation.

  1. 21. Effect of DNAJB6 on α-synuclein amyloid fibril aggregation and dis-aggregation

    Uppsats för yrkesexamina på avancerad nivå, Lunds universitet/Biofysikalisk kemi

    Författare :Josef Getachew; [2023]
    Nyckelord :α-synuclein; alpha-synuclein; chaperones; DNAJB6; the unhappy chaperone; parkinsons disease; biophysical chemistry; biochemistry; Biology and Life Sciences; Chemistry; Technology and Engineering;

    Sammanfattning : Amyloid proteins are a group of proteins with the ability to form large fibrillar aggregates, identifiable by their cross-β core structure. These aggregates are linked to several different neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease and due to the growing rate of people diagnosed, there is a need to combat these diseases. LÄS MER

  3. 22. Characterization of potato protein and its calcium binding capacity

    Master-uppsats, Lunds universitet/Beräkningskemi; Lunds universitet/Tillämpad biokemi

    Författare :Signe König; Erika Thomson; [2023]
    Nyckelord :Patatin; Calcium; Food supplement; Calcium Assay; Alcalase; potato protein; Applied biochemistry; Biology and Life Sciences; Technology and Engineering;

    Sammanfattning : Calcium is essential for the human body as it has functions in the nervous system, bones and formation of teeth. Deficiency in this important nutrient can be detrimental to health and cause life-long issues. Calcium can be found in various foods, like dairy products, but certain plant-based alternatives to milk needs to be fortified with calcium. LÄS MER

  4. 23. Optimization of two high-performance size-exclusion chromatography methods with diode-array detection for protein quantification and purity assessment

    Master-uppsats, Lunds universitet/Centrum för analys och syntes

    Författare :Camilla Lane; [2023]
    Nyckelord :Method qualification; Protein concentration; Protein Purity; High Performance Size exclusion chromatography; Quality control; Analytical chemistry; Biology and Life Sciences;

    Sammanfattning : Background: There is a need to develop methods of determining concentration and purity for two new affinity ligands, protein T and protein H, in order to ensure the quality of an industrial production of said proteins. Aims: To develop a High Performance Size Exclusion Chromatography, HPSEC, method to determine concentration and purity of protein T and to improve an existing HPSEC method for concentration and purity determination of protein H that show selectivity, display linearity between peak area and injection amount and give repeatable results. LÄS MER

  5. 24. Study of surfactant-preservative and protein-preservative interactions in multi-dose injectable formulation

    Master-uppsats, Lunds universitet/Livsmedelsteknik och nutrition (master)

    Författare :Javier Lagares Martín; [2023]
    Nyckelord :Phenol; polysorbate 80; cloud point; somatropin; aggregation; titration; light scattering; salt; surfactant; preservative; protein; tonicity adjusting agents; multi-dose injectable formulation; pharmaceutical technology; Technology and Engineering;

    Sammanfattning : Multidose injectable formulations require a preservative such as phenol to ensure sterility and protection against microbial contamination during clinical use. However, it is known that the interaction between these components and non-ionic surfactants such as polysorbate 80, also found in this type of formulations, present incompatibilities, which can lead to decreases in the efficacy of the product. LÄS MER

  7. 25. Efficient Utilization of Video Embeddings from Video-Language Models

    Master-uppsats, Linköpings universitet/Datorseende

    Författare :Felix Lindgren; [2023]
    Nyckelord :VLM; CLIP; transformers; machine learning; video retrieval; activitynet; efficient training; aggregation;

    Sammanfattning : In the digital age where video content is abundant, this thesis investigates the efficient adaptation of an existing video-language model (VLM) to new data. The research leverages CLIP, a robust language-vision model, for various video-related tasks including video retrieval. LÄS MER