Sökning: "protein conformational ensembles"
Hittade 3 uppsatser innehållade orden protein conformational ensembles.
1. Determining Protein Conformational Ensembles by Combining Machine Learning and SAXS
Master-uppsats, KTH/Tillämpad fysikSammanfattning : In structural biology, immense effort has been put into discovering functionally relevant atomic resolution protein structures. Still, most experimental, computational and machine learning-based methods alone struggle to capture all the functionally relevant states of many proteins without very involved and system-specific techniques. LÄS MER
2. Benchmarking a memetic algorithm for global all-atom protein-protein docking with backbone flexibility
Kandidat-uppsats, Lunds universitet/Kemiska institutionenSammanfattning : Determining how proteins interact with each other to form complexes is very important for understanding both disease and cellular functions, but experimentally determining the structures of these complexes is both tedious and slow, which is why a great number of protein-protein docking algorithms have been developed to predict them. To this day, conformational changes in protein backbones have been one of the largest challenges when making docking predictions. LÄS MER
3. Analysing ConformationalEnsembles using Machine Learning
Kandidat-uppsats, KTH/Skolan för teknikvetenskap (SCI)Sammanfattning : G-protein coupled receptors are involved in many diseases and act as target for severalpharmaceutical drugs. To develop methods to understand the dynamics of proteinsinvolved in the communication through the cell membrane is therefore crucial. LÄS MER
