Sökning: "DSF"
Visar resultat 1 - 5 av 18 uppsatser innehållade ordet DSF.
1. Structural and Functional Characterisation of the Human Mitochondrial Pyruvate Carrier
Master-uppsats, Lunds universitet/Kemiska institutionenSammanfattning : The metabolism of pyruvate in the cell is abnormally regulated in several human diseases, such as type-II diabetes, cancer and neurodegenerative disorders, in which the human mitochondrial pyruvate carrier (HuMPC) sits at a pivotal point. It transports pyruvate across the inner mitochondrial membrane and consists of two proteins, MPC1 and MPC2, and is a potential drug target against these diseases. LÄS MER
2. Investigation of the function of the SH3-like domain of the Saccharopolyspora erythraea iron-dependent regulator
Master-uppsats, Uppsala universitet/Institutionen för kemi - BMCSammanfattning : The bacterium Saccharopolyspora erythraea is utilized to produce the widely used antibiotic erythromycin. With the increasing problem of antibiotic resistance, the development of derivatives of the drug is of great importance. To produce antibiotics biosynthetically, it is crucial to understand the metabolic pathways utilized by the bacterium. LÄS MER
3. Biophysical characterization of and screening for binders and potentiator compounds that modulate the binding of PDZ domains to the C-terminal peptide motifs of target proteins
Master-uppsats, KTH/ProteinvetenskapSammanfattning : The N-methyl-D-aspartate receptor (NMDAR) hypofunctional hypothesis is believed to explain one of the contributing factors to schizophrenia. This hypothesis suggests the dysregulation of NMDAR, a protein responsible for receiving signals from the synapses between neurons, is the cause of some of the symptoms seen in schizophrenia. LÄS MER
4. Machine Unlearning and hyperparameters optimization in Gaussian Process regression
Master-uppsats, KTH/Skolan för elektroteknik och datavetenskap (EECS)Sammanfattning : The establishment of the General Data Protection Regulation (GDPR) in Europe in 2018, including the "Right to be Forgotten" poses important questions about the necessity of efficient data deletion techniques for trained Machine Learning models to completely enforce this right, since retraining from scratch such models whenever a data point must be deleted seems impractical. We tackle such a problem for Gaussian Process Regression and define in this paper an efficient exact unlearning technique for Gaussian Process Regression which completely include the optimization of the hyperparameters of the kernel function. LÄS MER
5. Fragment-screening by X-ray crystallography of human vaccinia related kinase 1
Master-uppsats, Linköpings universitet/Institutionen för fysik, kemi och biologiSammanfattning : Fragment-screening by X-ray crystallography (XFS) is an expensive and low throughput fragment drug discovery screening method, and it requires a lot of optimization for each protein target. The advantages with this screening method are that it is very sensitive, it directly gives the three-dimensional structure of the protein-fragment complexes, and false positives are rarely obtained. LÄS MER
